PureLean Natural Vanilla Bean Flavor

• Calories

  110 Calories

• Total Fat

  From 1 Gram Saturated Fat

  2.5 Grams

• Total Carbohydrates

  From 4 Grams Dietary Fiber

  From 3 Grams Total Sugars

  8 Grams

• Protein

  15 Grams

  Ingredient research · Protein

  Protein is a concentrated way to supply amino acids needed to build and repair body tissues. Supplementation can help meet higher or otherwise unmet protein needs, supporting muscle growth and exercise recovery when paired with training and helping preserve muscle during aging, illness, or calorie restriction.

  • Supports selected muscle-strength outcomes when increased protein intake accompanies resistance training.
  • Supports selected muscle-mass outcomes when protein supplementation accompanies resistance exercise in community-dwelling older adults with sarcopenia.
  • Supports a selected post-meal hunger outcome under a controlled high-protein weight-loss diet.

  Top References

  • Synergistic Effect of Increased Total Protein Intake and Strength Training on Muscle Strength: A Dose-Response Meta-analysis of Randomized Controlled Trials
  • The effectiveness of protein supplementation combined with resistance exercise programs among community-dwelling older adults with sarcopenia: a systematic review and meta-analysis
  • Responses in gut hormones and hunger to diets with either high protein or a mixture of protein plus free amino acids supplied under weight-loss conditions

• Vitamin A

  450 mcg

  Ingredient research · Vitamin A

  Vitamin A is an essential fat-soluble nutrient that enables normal vision, especially in dim light, and helps maintain immune defenses, skin and other epithelial tissues, growth, and reproduction. Supplementation can prevent or correct deficiency when intake or absorption is inadequate, benefiting visual, immune, and developmental health.

  • Supports maternal and breast-milk vitamin A status, particularly where baseline stores are low.
  • Supports hemoglobin response in some anemic or vitamin A-deficient populations, including when added to iron and folate.
  • Supports reducing bacterial-vaginosis incidence and prevalence during pregnancy and postpartum follow-up in a studied deficient setting.

  Top References

  • Efect of vitamin A suplementation: a systematic review.
  • Retinol-to-Fat Ratio and Retinol Concentration in Human Milk Show Similar Time Trends and Associations with Maternal Factors at the Population Level: A Systematic Review and Meta-Analysis.
  • Vitamin A supplementation for postpartum women.
  • Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh.
  • Weekly supplementation with iron and vitamin A during pregnancy increases hemoglobin concentration but decreases serum ferritin concentration in Indonesian pregnant women.
  • Maternal vitamin A and β-carotene supplementation and risk of bacterial vaginosis: a randomized controlled trial in rural Bangladesh.

• Vitamin C

  30 mg

  Ingredient research · Vitamin C

  Vitamin C is an essential water-soluble nutrient that supports collagen production, antioxidant defenses, and the normal function of immune cells. Supplementation reliably prevents or corrects deficiency, can improve absorption of plant-based iron, and may modestly shorten the duration of common colds when taken regularly.

  • Supports lower common-cold risk during brief periods of severe physical exercise or cold stress.
  • Supports circulating Vitamin C status across studied healthy and clinical populations.
  • Supports short-term blood-pressure and endothelial-function outcomes in studied adults.
  • Supports fasting-glucose and HbA1c outcomes in adults with type 2 diabetes.

  Top References

  • Vitamin C for preventing and treating the common cold.
  • Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review
  • High-dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males.
  • Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials.
  • Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials
  • Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
  • Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial
  • Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

• Vitamin D(400 IU)

  10 mcg

  Ingredient research · Vitamin D

  Vitamin D is a hormone-like nutrient that helps the body absorb calcium and maintain healthy bones and muscle function. Supplementation can reliably prevent or correct low vitamin D status, particularly when sun exposure is limited, while broader immune, cardiovascular, and metabolic benefits are less certain.

  • Supports bone-density and fracture- or fall-related outcomes.
  • Supports muscle-strength outcomes, including lower-limb strength.
  • Supports glycemic-marker and insulin-sensitivity outcomes in studied metabolic populations.
  • Supports respiratory-infection-risk outcomes across studied age groups.

  Top References

  • Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
  • What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta‐analysis
  • Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis.
  • Effect of Vitamin D Supplementation on Muscle Strength, Gait and Balance in Older Adults: A Systematic Review and Meta‐Analysis
  • The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials.
  • Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis
  • What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails
  • The Effect of Vitamin D Supplementation on Glycaemic Control in Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
  • The Role of Vitamin D Oral Supplementation in Insulin Resistance in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  • Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
  • Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.
  • Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Vitamin E

  10 mg

  Ingredient research · Vitamin E

  Vitamin E is an essential fat-soluble antioxidant that protects cell membranes from oxidative damage and supports normal immune and nerve function. Supplementation is most useful for preventing or correcting deficiency, particularly when fat absorption is impaired; routine use has not shown broad protection against cardiovascular disease or cancer.

  • Supports improvement in liver histology in adults without diabetes who have biopsy-confirmed nonalcoholic steatohepatitis.
  • Supports lower CRP and malondialdehyde in studied adult populations, including people receiving hemodialysis.
  • Supports short-term improvements in fasting glucose and HbA1c in adults with type 2 diabetes.

  Top References

  • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.
  • The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials
  • The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis
  • Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes.
  • Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

• Vitamin K

  40 mcg

  Ingredient research · Vitamin K

  Vitamin K is an essential fat-soluble nutrient that activates proteins needed for normal blood clotting and bone mineralization. Supplements reliably prevent or correct deficiency and may support bone health when intake or absorption is inadequate; effects beyond this, including cardiovascular benefits, are less certain and can differ between K1 and K2 forms.

• Thiamine

  0.75 mg

  Ingredient research · Thiamine

  Thiamine is vitamin B1, an essential nutrient that helps convert carbohydrates into usable energy and supports normal nerve and heart function. Supplementation reliably prevents or corrects deficiency, with particular relevance when absorption or intake is impaired, including in chronic heavy alcohol use.

  • Supports depression-treatment response when used alongside standard antidepressant treatment.

  Top References

  • Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial

• Riboflavin

  0.85 mg

  Ingredient research · Vitamin B2

  Vitamin B2 is riboflavin, an essential nutrient that helps enzymes release energy from food and supports normal red blood cell, skin, and nervous-system function. Supplementation reliably prevents or corrects deficiency, and regular use can reduce migraine frequency and severity in some people.

  • Supports blood-pressure control in treated hypertensive adults with the MTHFR 677TT genotype.

  Top References

  • Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.
  • Blood Pressure in Treated Hypertensive Individuals With the MTHFR 677TT Genotype Is Responsive to Intervention With Riboflavin: Findings of a Targeted Randomized Trial

• Niacin

  10 mg

  Ingredient research · Niacin

  Niacin is vitamin B3, essential for enzymes that convert food into energy and support normal skin and nervous-system function. Supplementation prevents or corrects deficiency; in high-dose nicotinic acid form it can alter cholesterol and triglycerides, but this pharmacologic use is distinct from routine nutritional supplementation.

  • Supports favorable changes in selected cholesterol fractions, including LDL, HDL, and total cholesterol, in studied metabolic and diabetes populations.
  • Supports favorable fasting-triglyceride changes in studied adults with diabetes or metabolic dysregulation.

  Top References

  • Effectiveness of niacin supplementation for patients with type 2 diabetes
  • Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials.
  • Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes
  • Postprandial triglyceride responses to aerobic exercise and extended-release niacin.

• Vitamin B6

  1 mg

  Ingredient research · Vitamin B6

  Vitamin B6 is an essential nutrient that helps enzymes process amino acids and supports neurotransmitter, hemoglobin, and immune function. Supplementation reliably corrects deficiency and can reduce nausea during pregnancy; outside these uses, it is most relevant when intake or absorption is inadequate.

  • Supports depressive-symptom measures in premenopausal women with hormone-related contexts.

  Top References

  • The role for vitamin B-6 as treatment for depression: a systematic review.
  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial

• Metafolin

  From 200 mcg L-5-Methyltetrahydrofolate

  333 mcg DFE

• Vitamin B12

  6 mcg

  Ingredient research · Vitamin B12

  Vitamin B12 is an essential nutrient needed for red blood cell formation, DNA synthesis, and normal nerve function. Supplementation reliably prevents or corrects deficiency—especially when intake or absorption is limited—and may improve anemia, fatigue, or neurologic symptoms caused by low B12, but is not a general energy booster when status is adequate.

  • Supports vitamin B12 status and responsive deficiency markers in low-status populations, including maternal and breast-milk status during pregnancy and early lactation.

  Top References

  • Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.
  • A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
  • Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status.

• Biotin

  150 mcg

  Ingredient research · Biotin

  Biotin is an essential B vitamin that helps enzymes process fats, carbohydrates, and amino acids. Supplementation reliably prevents or corrects deficiency, but extra biotin has not been shown to improve hair, skin, or nails in most people who are not deficient, and high intakes can distort certain laboratory test results.

• Pantothenic Acid

  5 mg

  Ingredient research · Vitamin B5

  Vitamin B5 is an essential nutrient used to make coenzyme A, a molecule central to releasing energy from food and building and breaking down fats. Supplementation prevents or corrects deficiency, but deficiency is uncommon and taking extra pantothenic acid has no clearly established benefit for most otherwise well-nourished people.

• Calcium(naturally occurring and as calcium citrate)

  220 mg

  Ingredient research · Calcium

  Calcium is an essential mineral that gives bones and teeth their structure and also enables muscle contraction and nerve signaling. Supplements are most useful for filling inadequate intake and, often alongside vitamin D, can help preserve bone mineral density and support fracture prevention in some higher-risk groups.

  • Supports bone-mineral-density outcomes in studied healthy children and older women.

  Top References

  • Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials
  • The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial

• Iron(naturally occurring)

  1 mg

  Ingredient research · Iron

  Iron is an essential mineral needed to make hemoglobin and carry oxygen throughout the body. Supplementation can reliably prevent or correct iron-deficiency anemia, helping restore energy, exercise capacity, and cognitive function when low iron is the cause; it is also commonly used when requirements rise, such as during pregnancy.

  • Supports hemoglobin and iron stores in menstruating women, especially when iron status is low.
  • Supports reduced subjective fatigue in iron-deficient adults without anemia.
  • Supports selected maximal and submaximal exercise-performance measures in women of reproductive age, particularly those who are iron-deficient or trained.
  • Supports selected attention and concentration outcomes in older children and women.

  Top References

  • Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
  • Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials
  • Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis.
  • The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis

• Phosphorus(naturally occurring)

  100 mg

  Ingredient research · Phosphorus

  Phosphorus is an essential dietary mineral that helps build bones and teeth and is integral to cellular energy, cell membranes, and acid–base balance. Supplements are mainly relevant when intake or absorption is inadequate; most diets already provide enough, and excess phosphorus can be problematic, especially with impaired kidney function.

• Iodine

  75 mcg

  Ingredient research · Iodine

  Iodine is an essential mineral the thyroid uses to make hormones that regulate metabolism, growth, and development. Supplementation reliably prevents or corrects iodine deficiency and is especially important when needs rise during pregnancy for fetal brain development, but excess intake can also disturb thyroid function.

  • Supports selected micronutrient and thyroid-status markers in iodine-deficient adults.

  Top References

  • Iodine Supplementation of Mildly Iodine-Deficient Adults Lowers Thyroglobulin: A Randomized Controlled Trial.
  • Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.

• Magnesium(naturally occurring and as magnesium citrate)

  100 mg

  Ingredient research · Magnesium

  Magnesium is an essential mineral that enables normal muscle and nerve function, energy production, heart rhythm, and bone maintenance. Supplements can correct low magnesium status and, depending on the formulation, may also help with constipation, muscle cramps, or migraine prevention in some people.

• Zinc

  11 mg

  Ingredient research · Zinc

  Zinc is an essential mineral needed for hundreds of enzymes, DNA and protein synthesis, immune defense, wound healing, and normal growth. Supplementation corrects low zinc status and helps restore these functions; certain zinc lozenges may also modestly shorten a common cold when used early, though this benefit depends on the formulation.

• Selenium

  35 mcg

  Ingredient research · Selenium

  Selenium is an essential trace mineral used to make antioxidant enzymes and regulate thyroid hormone activity, linking adequate intake to thyroid, immune, and reproductive function. Supplementation can correct low selenium status, but more is not necessarily better because excessive intake can be toxic.

  • Supports selected thyroid-autoantibody and TSH markers in studied people with autoimmune thyroiditis.
  • Supports selected antioxidant-defense biomarkers in studied metabolic, cardiovascular, and selenium-status populations.
  • Supports depression-symptom measures across a small selenium-specific randomized evidence base.

  Top References

  • Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.
  • Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto’s thyroiditis: A prospective randomized‐controlled trial
  • Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials
  • The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials.
  • Methods of assessment of selenium status in humans: a systematic review.
  • The role of selenium in depression: a systematic review and meta-analysis of human observational and interventional studies

• Chromium

  60 mcg

  Ingredient research · Chromium

  Chromium is a trace mineral thought to assist insulin action and the metabolism of carbohydrates, fats, and proteins. Supplements are mainly used to improve blood sugar control, though benefits are usually modest or inconsistent outside rare deficiency; the trivalent chromium in supplements is distinct from toxic industrial hexavalent chromium.

• Sodium(naturally occurring)

  375 mg

  Ingredient research · Sodium

  Sodium is an essential electrolyte that maintains fluid balance and supports nerve signaling and muscle contraction. Supplementation is mainly useful for replacing losses from heavy sweating, prolonged exercise, or fluid loss from illness, often as part of an electrolyte or oral rehydration formula; excess intake can raise blood pressure.

• Superfruit Antioxidant Blend

  100 mg

  • Pomegranate Fruit Extract

    Ingredient research · Pomegranate

    Pomegranate is a polyphenol-rich fruit used in supplements, typically as juice concentrates or extracts, for its antioxidant and vascular effects. Pomegranate may modestly support blood pressure and blood-vessel function, with possible relevance to exercise recovery and metabolic health, though benefits depend on the preparation.

  • Acerola Berry Extract

  • Quercetin

    Ingredient research · Quercetin

    Quercetin is a plant flavonoid with antioxidant and inflammation-modulating activity, commonly taken for immune, cardiovascular, and allergy-related support. Human benefits appear modest and context-dependent: it may slightly improve blood pressure and some inflammatory markers, while its usefulness for preventing infections or relieving allergy symptoms remains uncertain.

    • Supports LDL and total-cholesterol markers in adults with metabolic disorders.
    • Supports selected insulin-sensitivity and adipokine markers in women with polycystic ovary syndrome.
    • Supports disease-activity and joint-symptom measures in women with rheumatoid arthritis.
    • Supports neuromuscular recovery and selected muscle-damage markers after eccentric exercise.

    Top References

    • The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials
    • Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Double-Blind Clinical Trial
    • The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome
    • The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial
    • The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage
    • Quercetin Supplementation Improves Neuromuscular Function Recovery from Muscle Damage

  • Acai, Powder

    Ingredient research · Acai Berry

    Acai Berry is a dark-purple fruit rich in anthocyanins and other polyphenols, usually supplemented as powders or extracts for its antioxidant appeal. Although it may influence short-term markers of oxidative stress or metabolism, meaningful benefits for weight management, cardiovascular health, or immune function remain uncertain.

  • Blueberry Fruit Extract

    Ingredient research · Blueberry Leaf

    Blueberry Leaf is the leaf of lowbush blueberry, not the fruit; it contains polyphenols and has traditionally been used in teas and extracts aimed at blood-sugar and metabolic support. These uses are driven mainly by laboratory findings and traditional practice, with little human evidence that the leaf itself provides meaningful benefits.

• DNF-10 Yeast Hydrolysate

  500 mg

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