Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial
What this study found
Vitamin C supplementation produced a favorable short-term effect on inflammation and glycemic control, but not on lipids. In the Vitamin C group, hs-CRP fell from 14.86±9.20 to 7.74±4.53 (P=0.01), IL-6 from 2.20±0.75 to 1.40±0.53 (P=0.001), and fasting blood glucose from 188.13±81.24 to 126.16±34.06 (P=0.001). Total cholesterol did not change significantly (207.71±36.20 to 196.48±33.89, P=0.071), and triglycerides also did not show a significant change (223.81±87.88 to 155.10±48.12, P=0.138). Between-group endpoint comparisons were also significant for hs-CRP (P=0.01), IL-6 (P=0.001), and…
- Study & population
- Randomized controlled trial in obese adults with hypertension and/or type 2 diabetes attending primary health care centers in Gaza City, Palestine.
- Intervention
- Vitamin C tablets (C-Tamin-500) were given at 500 mg twice daily for 8 weeks, for a total daily dose of 1 g.
- Key limitation
- The intervention was short term (8 weeks) and evaluated in a relatively small, single-region sample of obese adults with hypertension and/or diabetes, limiting generalizability.
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Open PDFOriginal abstract
Background Obesity is well associated as being an interfering factor in metabolic diseases such as hypertension and diabetes by increasing the secretion of proinflammatory markers from adipose tissue. Having healthy effects, vitamin C could work as an anti-inflammatory agent through its antioxidant capacity. Registration Registration number: FPSK_Mac [13]04. Objective The aim of the study reported here was to identify the effect of vitamin C on reducing the levels of inflammatory markers in hypertensive and/or diabetic obese adults. Subjects and methods Sixty-four obese patients, who were hypertensive and/or diabetic and had high levels of inflammatory markers, from primary health care centers in Gaza City, Palestine, were enrolled into one of two groups in an open-label, parallel, randomized controlled trial. A total of 33 patients were randomized into a control group and 31 patients were randomized into an experimental group. The experimental group was treated with 500 mg vitamin C twice a day. Results In the experimental group, vitamin C significantly reduced the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), fasting blood glucose (FBG), and triglyceride (TG) after 8 weeks of treatment (overall: P<0.001); no changes appeared in total cholesterol (TC). In the control group, there were significant reductions in FBG and TG (P=0.001 and P=0.026, respectively), and no changes in hs-CRP, IL-6, or TC. On comparing the changes in the experimental group with those in the control group at the endpoint, vitamin C was found to have achieved clinical significance in treating effectiveness for reducing hs-CRP, IL-6, and FBG levels (P=0.01, P=0.001, and P<0.001, respectively), but no significant changes in TC or TG were found. Conclusion Vitamin C (500 mg twice daily) has potential effects in alleviating inflammatory status by reducing hs-CRP, IL-6, and FBG in hypertensive and/or diabetic obese patients.