Research paper
Methods of assessment of selenium status in humans: a systematic review.
The American journal of clinical nutrition
Q1
Citations: 213
Influential: 10
Systematic Reviews / Meta-Analyses
84
Study answer
What this study found
Selenium supplementation consistently changed several biomarkers, supporting plasma selenium, erythrocyte selenium, whole-blood selenium, plasma selenoprotein P, and plasma, platelet, and whole-blood glutathione peroxidase activity as useful indicators of selenium status. Plasma selenium increased with supplementation (WMD: 0.90 lmol/L; 95% CI: 0.67, 1.14; 14 studies, 512 participants), and similar pooled increases were seen for erythrocyte selenium, whole-blood selenium, urinary selenium, GPx activity, and plasma selenoprotein P. Evidence was insufficient for urinary selenium, plasma T3:T4…
- Study & population
- Systematic review of human supplementation studies assessing biomarkers of selenium status.
- Intervention
- Active interventions were selenium supplementation regimens used to probe biomarker responsiveness, most commonly selenomethionine or selenium-enriched/high-selenium yeast.
- Key limitation
- The evidence base was heterogeneous, with widely varying selenium forms, doses, populations, and intervention durations.
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