Research paper
The Effect of Vitamin D Supplementation on Glycaemic Control in Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Study answer
What this study found
Vitamin D supplementation during pregnancy was associated with better glycaemic control in women with gestational diabetes, with improvements seen most consistently in fasting blood glucose, glycated haemoglobin, and serum insulin. Individual trials reported significant reductions in fasting glucose, such as -17.12 ± 14.84 vs -0.96 ± 16.64 mg/dL (p < 0.001) and -9.9 ± 7.2 vs 2.9 ± 7.6 mg/dL (p = 0.04), and some trials also showed lower HbA1c, including -0.18% ± 0.48% vs 0.17% ± 0.39% (p = 0.02). However, results were not uniform across all studies or outcomes, with some insulin and glucose…
- Study & population
- Systematic review and meta-analysis of 5 randomized controlled trials conducted in Iran and China.
- Intervention
- Vitamin D supplementation during pregnancy was evaluated in several randomized trials among women with gestational diabetes mellitus, using a range of regimens including oral vitamin D3 capsules, vitamin D3-fortified yogurt, and a single intramuscular vitamin D dose.
- Key limitation
- The evidence base was limited to 5 randomized trials, with all studies conducted in Iran or China, which restricts generalizability.
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Open PDFOriginal abstract
Vitamin D deficiency is highly prevalent amongst pregnant women and is linked to a range of adverse complications, including gestational diabetes. However, there is no consensus among researchers regarding the impact of vitamin D supplementation in a…