Ultra BoneUp

• Vitamin C

  66.7 mg

  Ingredient research · Vitamin C

  Vitamin C is an essential water-soluble nutrient that supports collagen production, antioxidant defenses, and the normal function of immune cells. Supplementation reliably prevents or corrects deficiency, can improve absorption of plant-based iron, and may modestly shorten the duration of common colds when taken regularly.

  • Supports lower common-cold risk during brief periods of severe physical exercise or cold stress.
  • Supports circulating Vitamin C status across studied healthy and clinical populations.
  • Supports short-term blood-pressure and endothelial-function outcomes in studied adults.
  • Supports fasting-glucose and HbA1c outcomes in adults with type 2 diabetes.

  Top References

  • Vitamin C for preventing and treating the common cold.
  • Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review
  • High-dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males.
  • Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials.
  • Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials
  • Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
  • Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial
  • Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

• Vitamin D(667 IU)

  16.7 mcg

  Ingredient research · Vitamin D

  Vitamin D is a hormone-like nutrient that helps the body absorb calcium and maintain healthy bones and muscle function. Supplementation can reliably prevent or correct low vitamin D status, particularly when sun exposure is limited, while broader immune, cardiovascular, and metabolic benefits are less certain.

  • Supports bone-density and fracture- or fall-related outcomes.
  • Supports muscle-strength outcomes, including lower-limb strength.
  • Supports glycemic-marker and insulin-sensitivity outcomes in studied metabolic populations.
  • Supports respiratory-infection-risk outcomes across studied age groups.

  Top References

  • Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
  • What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta‐analysis
  • Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis.
  • Effect of Vitamin D Supplementation on Muscle Strength, Gait and Balance in Older Adults: A Systematic Review and Meta‐Analysis
  • The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials.
  • Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis
  • What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails
  • The Effect of Vitamin D Supplementation on Glycaemic Control in Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
  • The Role of Vitamin D Oral Supplementation in Insulin Resistance in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  • Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
  • Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.
  • Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Calcium(elemental)

  400 mg

  Ingredient research · Calcium

  Calcium is an essential mineral that gives bones and teeth their structure and also enables muscle contraction and nerve signaling. Supplements are most useful for filling inadequate intake and, often alongside vitamin D, can help preserve bone mineral density and support fracture prevention in some higher-risk groups.

  • Supports bone-mineral-density outcomes in studied healthy children and older women.

  Top References

  • Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials
  • The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial

• Magnesium

  166.7 mg

  Ingredient research · Magnesium

  Magnesium is an essential mineral that enables normal muscle and nerve function, energy production, heart rhythm, and bone maintenance. Supplements can correct low magnesium status and, depending on the formulation, may also help with constipation, muscle cramps, or migraine prevention in some people.

• Zinc

  3.3 mg

  Ingredient research · Zinc

  Zinc is an essential mineral needed for hundreds of enzymes, DNA and protein synthesis, immune defense, wound healing, and normal growth. Supplementation corrects low zinc status and helps restore these functions; certain zinc lozenges may also modestly shorten a common cold when used early, though this benefit depends on the formulation.

• Copper

  0.33 mg

  Ingredient research · Copper

  Copper is an essential trace mineral used by enzymes that support iron metabolism, connective-tissue formation, energy production, antioxidant defense, and nervous and immune function. Supplementation can correct low copper status and related anemia or neurologic problems, but extra copper offers no established benefit when intake and status are adequate.

• Manganese

  0.33 mg

  Ingredient research · Manganese

  Manganese is an essential trace mineral that activates enzymes involved in energy metabolism, connective-tissue and bone formation, and antioxidant defense. Supplementation can restore these functions when intake is inadequate or deficiency is present, but added manganese has no clear general benefit for people who already get enough.

• Potassium

  33 mg

  Ingredient research · Potassium

  Potassium is an essential electrolyte that helps regulate fluid balance, nerve signaling, and muscle contraction, including the heartbeat. Supplementation is most useful for preventing or correcting low potassium when intake is inadequate or losses are increased, while adequate potassium intake also contributes to healthy blood pressure.

  • Supports blood-pressure control, particularly in adults with hypertension and higher sodium or lower potassium intake.
  • Supports selected vascular-function responses after high-sodium meals in healthy adults.

  Top References

  • The effect of potassium supplementation on blood pressure in hypertensive subjects: A systematic review and meta-analysis.
  • Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial.
  • Postprandial effects of potassium supplementation on vascular function and blood pressure: a randomised cross-over study.

• Silicon(molecular clusters of stabilized silicic acid)

  3.33 mg

  Ingredient research · Silicon

  Silicon is a trace element involved in connective-tissue and bone biology, which motivates its use for skeletal health and collagen-rich tissues such as skin, hair, and nails. Supplementation may support bone formation, but benefits in people with adequate intake remain uncertain; supplement forms also differ substantially in absorption, and silicon is not silicone.

• Vitamin K2(naturally derived)

  40 mcg

  Ingredient research · Vitamin K2

  Vitamin K2 is a family of menaquinones that activates proteins involved in normal blood clotting, bone mineralization, and calcium regulation. Supplements are mainly used to support bone health, while possible benefits for vascular calcification and cardiovascular health remain less certain and may differ among forms such as MK-4 and MK-7.

  • Supports selected osteocalcin carboxylation markers in postmenopausal osteoporosis.

  Top References

  • Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review

• Boron

  1 mg

  Ingredient research · Boron

  Boron is a trace element that may influence mineral metabolism and the actions of vitamin D and steroid hormones. Supplements are mainly considered for bone and joint health, but a distinct benefit in people with adequate diets has not been firmly established.

• Type II Collagen

  16.66 mg

  Ingredient research · Collagen Type II

  Collagen Type II is the main structural collagen in cartilage, making it chiefly relevant to joint health rather than the skin-focused uses associated with other collagen types. Supplements may modestly improve joint comfort and function, but native and hydrolyzed forms are distinct preparations that may act differently and should not be treated as interchangeable.

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