Acnutrol

• Vitamin A(Vitamin A (Form: as Vitamin A Palmitate))

  50000 IU

  Ingredient research · Vitamin A

  Vitamin A is an essential fat-soluble nutrient that enables normal vision, especially in dim light, and helps maintain immune defenses, skin and other epithelial tissues, growth, and reproduction. Supplementation can prevent or correct deficiency when intake or absorption is inadequate, benefiting visual, immune, and developmental health.

  • Supports maternal and breast-milk vitamin A status, particularly where baseline stores are low.
  • Supports hemoglobin response in some anemic or vitamin A-deficient populations, including when added to iron and folate.
  • Supports reducing bacterial-vaginosis incidence and prevalence during pregnancy and postpartum follow-up in a studied deficient setting.

  Top References

  • Efect of vitamin A suplementation: a systematic review.
  • Retinol-to-Fat Ratio and Retinol Concentration in Human Milk Show Similar Time Trends and Associations with Maternal Factors at the Population Level: A Systematic Review and Meta-Analysis.
  • Vitamin A supplementation for postpartum women.
  • Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh.
  • Weekly supplementation with iron and vitamin A during pregnancy increases hemoglobin concentration but decreases serum ferritin concentration in Indonesian pregnant women.
  • Maternal vitamin A and β-carotene supplementation and risk of bacterial vaginosis: a randomized controlled trial in rural Bangladesh.

• Vitamin D(Vitamin D (Form: as Cholecalciferol))

  2000 IU

  Ingredient research · Vitamin D

  Vitamin D is a hormone-like nutrient that helps the body absorb calcium and maintain healthy bones and muscle function. Supplementation can reliably prevent or correct low vitamin D status, particularly when sun exposure is limited, while broader immune, cardiovascular, and metabolic benefits are less certain.

  • Supports bone-density and fracture- or fall-related outcomes.
  • Supports muscle-strength outcomes, including lower-limb strength.
  • Supports glycemic-marker and insulin-sensitivity outcomes in studied metabolic populations.
  • Supports respiratory-infection-risk outcomes across studied age groups.

  Top References

  • Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
  • What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta‐analysis
  • Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis.
  • Effect of Vitamin D Supplementation on Muscle Strength, Gait and Balance in Older Adults: A Systematic Review and Meta‐Analysis
  • The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials.
  • Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis
  • What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails
  • The Effect of Vitamin D Supplementation on Glycaemic Control in Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
  • The Role of Vitamin D Oral Supplementation in Insulin Resistance in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  • Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
  • Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.
  • Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Vitamin E

  18 IU

  Ingredient research · Vitamin E

  Vitamin E is an essential fat-soluble antioxidant that protects cell membranes from oxidative damage and supports normal immune and nerve function. Supplementation is most useful for preventing or correcting deficiency, particularly when fat absorption is impaired; routine use has not shown broad protection against cardiovascular disease or cancer.

  • Supports improvement in liver histology in adults without diabetes who have biopsy-confirmed nonalcoholic steatohepatitis.
  • Supports lower CRP and malondialdehyde in studied adult populations, including people receiving hemodialysis.
  • Supports short-term improvements in fasting glucose and HbA1c in adults with type 2 diabetes.

  Top References

  • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.
  • The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials
  • The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis
  • Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes.
  • Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

• Niacin(Niacin (Form: as Niacinamide, Vitamin B-3))

  500 mg

  Ingredient research · Niacin

  Niacin is vitamin B3, essential for enzymes that convert food into energy and support normal skin and nervous-system function. Supplementation prevents or corrects deficiency; in high-dose nicotinic acid form it can alter cholesterol and triglycerides, but this pharmacologic use is distinct from routine nutritional supplementation.

  • Supports favorable changes in selected cholesterol fractions, including LDL, HDL, and total cholesterol, in studied metabolic and diabetes populations.
  • Supports favorable fasting-triglyceride changes in studied adults with diabetes or metabolic dysregulation.

  Top References

  • Effectiveness of niacin supplementation for patients with type 2 diabetes
  • Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials.
  • Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes
  • Postprandial triglyceride responses to aerobic exercise and extended-release niacin.

• Vitamin B6

  From 40 mg Pyridoxine Hydrochloride

  From 10 mg Pyridoxal 5-Phosphate

  50 mg

  Ingredient research · Vitamin B6

  Vitamin B6 is an essential nutrient that helps enzymes process amino acids and supports neurotransmitter, hemoglobin, and immune function. Supplementation reliably corrects deficiency and can reduce nausea during pregnancy; outside these uses, it is most relevant when intake or absorption is inadequate.

  • Supports depressive-symptom measures in premenopausal women with hormone-related contexts.

  Top References

  • The role for vitamin B-6 as treatment for depression: a systematic review.
  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial

• Pantothenic Acid

  2500 mg

  Ingredient research · Vitamin B5

  Vitamin B5 is an essential nutrient used to make coenzyme A, a molecule central to releasing energy from food and building and breaking down fats. Supplementation prevents or corrects deficiency, but deficiency is uncommon and taking extra pantothenic acid has no clearly established benefit for most otherwise well-nourished people.

• Zinc

  50 mg

  Ingredient research · Zinc

  Zinc is an essential mineral needed for hundreds of enzymes, DNA and protein synthesis, immune defense, wound healing, and normal growth. Supplementation corrects low zinc status and helps restore these functions; certain zinc lozenges may also modestly shorten a common cold when used early, though this benefit depends on the formulation.

• Selenium(Selenium (Form: as Selenium Glycinate Complex))

  100 mcg

  Ingredient research · Selenium

  Selenium is an essential trace mineral used to make antioxidant enzymes and regulate thyroid hormone activity, linking adequate intake to thyroid, immune, and reproductive function. Supplementation can correct low selenium status, but more is not necessarily better because excessive intake can be toxic.

  • Supports selected thyroid-autoantibody and TSH markers in studied people with autoimmune thyroiditis.
  • Supports selected antioxidant-defense biomarkers in studied metabolic, cardiovascular, and selenium-status populations.
  • Supports depression-symptom measures across a small selenium-specific randomized evidence base.

  Top References

  • Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.
  • Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto’s thyroiditis: A prospective randomized‐controlled trial
  • Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials
  • The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials.
  • Methods of assessment of selenium status in humans: a systematic review.
  • The role of selenium in depression: a systematic review and meta-analysis of human observational and interventional studies

• Copper

  2 mg

  Ingredient research · Copper

  Copper is an essential trace mineral used by enzymes that support iron metabolism, connective-tissue formation, energy production, antioxidant defense, and nervous and immune function. Supplementation can correct low copper status and related anemia or neurologic problems, but extra copper offers no established benefit when intake and status are adequate.

• Chromium

  400 mcg

  Ingredient research · Chromium

  Chromium is a trace mineral thought to assist insulin action and the metabolism of carbohydrates, fats, and proteins. Supplements are mainly used to improve blood sugar control, though benefits are usually modest or inconsistent outside rare deficiency; the trivalent chromium in supplements is distinct from toxic industrial hexavalent chromium.

• L-Carnitine(L-Carnitine (Form: from L-Carnitine Tartrate))

  500 mg

  Ingredient research · Carnitine

  Carnitine is a nutrient-like compound that shuttles long-chain fatty acids into mitochondria for energy production, making supplementation medically important when levels are deficient or depleted. Beyond replacement, it may modestly support exercise recovery and aspects of male fertility or cardiovascular health, though benefits depend on the population and form used.

  • Supports body-weight, BMI, and waist measurements in women with polycystic ovary syndrome.
  • Supports blood-glucose and insulin markers in women with polycystic ovary syndrome.
  • Supports depression, anxiety-and-stress, and general mental-health scores in women with polycystic ovary syndrome.

  Top References

  • Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled trial
  • Oral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

• Mixed Tocopherols(High Gamma Mixed Tocopherols (Form: as d-gamma {tocopherol}, d-delta {tocopherol}, d-alpha {tocopherol}, d-beta {tocopherol}))

  120 mg

  Ingredient research · Tocopherols

  Tocopherols are a family of fat-soluble vitamin E compounds that help protect cell membranes from oxidative damage; alpha-tocopherol is the form the body preferentially retains and uses to meet vitamin E needs. Supplements can prevent or correct deficiency, while claimed advantages of mixed tocopherols for broader cardiovascular or immune benefits remain uncertain.

• Biotin

  500 mcg

  Ingredient research · Biotin

  Biotin is an essential B vitamin that helps enzymes process fats, carbohydrates, and amino acids. Supplementation reliably prevents or corrects deficiency, but extra biotin has not been shown to improve hair, skin, or nails in most people who are not deficient, and high intakes can distort certain laboratory test results.

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