Nac

• N-Acetyl Cysteine

  1200 mg

  Ingredient research · NAC

  NAC is a cysteine derivative that helps replenish glutathione, a major cellular antioxidant, and also thins mucus by breaking bonds in its proteins. As a supplement, it may support antioxidant defenses and respiratory health; acetylcysteine also has established medical uses as a mucolytic and as an antidote for acetaminophen poisoning.

  • Supports glutathione and antioxidant-defense measures.
  • Supports depressive symptoms and negative symptoms of schizophrenia.
  • Supports cannabis-use, craving, and abstinence outcomes.
  • Evidence supports kidney-function and injury-marker outcomes in clinical treatment settings.
  • Supports hearing-loss and ototoxicity outcomes in noise- and medication-exposure settings.

  Top References

  • N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study
  • Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status.
  • N‐acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double‐blind controlled trial in healthy subjects
  • Meta-analysis of randomised controlled trials with N-acetylcysteine in the treatment of schizophrenia
  • N‐acetylcysteine for depression and glutamate changes in the left prefrontal cortex in adolescents and young adults at risk for bipolar disorder: A pilot study
  • N-acetyl cysteine in the treatment of cannabis use disorder: A systematic review of clinical trials.
  • A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.
  • N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis
  • A double-blinded, placebo-controlled, multicenter clinical trial of N-acetylcysteine for preventing amphotericin B-induced nephrotoxicity
  • A systematic review and meta-analysis of the efficacy and safety of N-acetylcysteine in preventing aminoglycoside-induced ototoxicity: implications for the treatment of multidrug-resistant TB
  • Protective effects of vitamins/antioxidants on occupational noise‐induced hearing loss: A systematic review
  • Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial

• Selenium

  100 mcg

  Ingredient research · Selenium

  Selenium is an essential trace mineral used to make antioxidant enzymes and regulate thyroid hormone activity, linking adequate intake to thyroid, immune, and reproductive function. Supplementation can correct low selenium status, but more is not necessarily better because excessive intake can be toxic.

  • Supports selected thyroid-autoantibody and TSH markers in studied people with autoimmune thyroiditis.
  • Supports selected antioxidant-defense biomarkers in studied metabolic, cardiovascular, and selenium-status populations.
  • Supports depression-symptom measures across a small selenium-specific randomized evidence base.

  Top References

  • Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.
  • Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto’s thyroiditis: A prospective randomized‐controlled trial
  • Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials
  • The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials.
  • Methods of assessment of selenium status in humans: a systematic review.
  • The role of selenium in depression: a systematic review and meta-analysis of human observational and interventional studies

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