Ester-C & Flavonoids

• Vitamin C(from Ester-C calcium ascorbate blend)

  619 mg

  Ingredient research · Vitamin C

  Vitamin C is an essential water-soluble nutrient that supports collagen production, antioxidant defenses, and the normal function of immune cells. Supplementation reliably prevents or corrects deficiency, can improve absorption of plant-based iron, and may modestly shorten the duration of common colds when taken regularly.

  • Supports lower common-cold risk during brief periods of severe physical exercise or cold stress.
  • Supports circulating Vitamin C status across studied healthy and clinical populations.
  • Supports short-term blood-pressure and endothelial-function outcomes in studied adults.
  • Supports fasting-glucose and HbA1c outcomes in adults with type 2 diabetes.

  Top References

  • Vitamin C for preventing and treating the common cold.
  • Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review
  • High-dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males.
  • Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials.
  • Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials
  • Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
  • Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial
  • Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

• Calcium(from Ester-C calcium ascorbate blend)

  68 mg

  Ingredient research · Calcium

  Calcium is an essential mineral that gives bones and teeth their structure and also enables muscle contraction and nerve signaling. Supplements are most useful for filling inadequate intake and, often alongside vitamin D, can help preserve bone mineral density and support fracture prevention in some higher-risk groups.

  • Supports bone-mineral-density outcomes in studied healthy children and older women.

  Top References

  • Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials
  • The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial

• Threonic Acid(from Ester-C calcium ascorbate blend)

  7 mg

• Quercetin

  50 mg

  Ingredient research · Quercetin

  Quercetin is a plant flavonoid with antioxidant and inflammation-modulating activity, commonly taken for immune, cardiovascular, and allergy-related support. Human benefits appear modest and context-dependent: it may slightly improve blood pressure and some inflammatory markers, while its usefulness for preventing infections or relieving allergy symptoms remains uncertain.

  • Supports LDL and total-cholesterol markers in adults with metabolic disorders.
  • Supports selected insulin-sensitivity and adipokine markers in women with polycystic ovary syndrome.
  • Supports disease-activity and joint-symptom measures in women with rheumatoid arthritis.
  • Supports neuromuscular recovery and selected muscle-damage markers after eccentric exercise.

  Top References

  • The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials
  • Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Double-Blind Clinical Trial
  • The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome
  • The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial
  • The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage
  • Quercetin Supplementation Improves Neuromuscular Function Recovery from Muscle Damage

• Rutin

  100 mg

  Ingredient research · Rutin

  Rutin is a plant flavonoid made of quercetin linked to a sugar group, and is taken mainly for its antioxidant activity and proposed support of capillary and venous function. Unlike some modified rutosides, Rutin itself has limited human evidence for circulatory benefits, while broader cardiometabolic or anti-inflammatory uses remain speculative.

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