Arginine Plus

• Total Carbohydrates

  From 1 Gram Dietary Fiber

  1 Gram

• Folate

  665 mcg DFE

  Ingredient research · Folate

  Folate is vitamin B9, an essential nutrient needed for DNA synthesis, cell division, and healthy red blood cell formation. Supplementation is especially important before conception and in early pregnancy because adequate folate reliably reduces neural tube defect risk, and it can also correct folate-deficiency anemia.

  • Supports homocysteine measures in women with PCOS and adults with metabolic syndrome.
  • Supports insulin and beta-cell-function markers in women with PCOS or cervical intraepithelial neoplasia.
  • Supports selected lipid-panel and vascular markers in women with PCOS and adults with metabolic syndrome.
  • Supports selected inflammation and oxidative-stress biomarkers in PCOS, metabolic syndrome, or cervical intraepithelial neoplasia.

  Top References

  • The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled clinical trial
  • Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.
  • The Effects of Folate Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Patients with Metabolic Syndrome
  • Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial.

• L-Arginine

  1.5 Grams

  Ingredient research · L-Arginine

  L-Arginine is an amino acid the body uses to make nitric oxide, a signaling molecule that relaxes blood vessels, and to build proteins and clear ammonia. Supplementation may improve blood flow and modestly benefit blood pressure or erectile function in some people, while exercise-performance benefits are less dependable.

  • Supports endothelial function and blood-flow responses.
  • Supports glucose-tolerance and insulin-response measures in adults with obesity or prediabetes.
  • Supports delayed progression to type 2 diabetes in adults with impaired glucose tolerance and metabolic syndrome.
  • Supports triglyceride markers.

  Top References

  • Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
  • l-Arginine Supplementation Alleviates Postprandial Endothelial Dysfunction When Baseline Fasting Plasma Arginine Concentration Is Low: A Randomized Controlled Trial in Healthy Overweight Adults with Cardiometabolic Risk Factors.
  • Effects of tree nut and groundnut consumption compared with those of l-arginine supplementation on fasting and postprandial flow-mediated vasodilation: Meta-analysis of human randomized controlled trials.
  • Effect of l-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study
  • Decreased diabetes risk over 9 year after 18-month oral l-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of l-arginine study)
  • The effect of l-arginine supplementation on lipid profile: a systematic review and meta-analysis of randomised controlled trials
  • Effect of L-Arginine Supplementation on Lipid Profiles and Inflammatory Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

• Glycine

  10 mg

  Ingredient research · Glycine

  Glycine is a simple amino acid used to build proteins—especially collagen—and to make glutathione and other important molecules; it also acts as an inhibitory neurotransmitter. Supplementation may modestly improve sleep quality and next-day alertness, while proposed metabolic and connective-tissue benefits are less certain.

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