B-Complex 50

• Riboflavin

  50 mg

  Ingredient research · Vitamin B2

  Vitamin B2 is riboflavin, an essential nutrient that helps enzymes release energy from food and supports normal red blood cell, skin, and nervous-system function. Supplementation reliably prevents or corrects deficiency, and regular use can reduce migraine frequency and severity in some people.

  • Supports blood-pressure control in treated hypertensive adults with the MTHFR 677TT genotype.

  Top References

  • Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.
  • Blood Pressure in Treated Hypertensive Individuals With the MTHFR 677TT Genotype Is Responsive to Intervention With Riboflavin: Findings of a Targeted Randomized Trial

• Thiamine(Thiamine (Form: as Thiamine Mononitrate) (Alt. Name: B-1))

  50 mg

  Ingredient research · Thiamine

  Thiamine is vitamin B1, an essential nutrient that helps convert carbohydrates into usable energy and supports normal nerve and heart function. Supplementation reliably prevents or corrects deficiency, with particular relevance when absorption or intake is impaired, including in chronic heavy alcohol use.

  • Supports depression-treatment response when used alongside standard antidepressant treatment.

  Top References

  • Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial

• Niacin(Niacin (Form: as Niacinamide, B-3))

  50 mg

  Ingredient research · Niacin

  Niacin is vitamin B3, essential for enzymes that convert food into energy and support normal skin and nervous-system function. Supplementation prevents or corrects deficiency; in high-dose nicotinic acid form it can alter cholesterol and triglycerides, but this pharmacologic use is distinct from routine nutritional supplementation.

  • Supports favorable changes in selected cholesterol fractions, including LDL, HDL, and total cholesterol, in studied metabolic and diabetes populations.
  • Supports favorable fasting-triglyceride changes in studied adults with diabetes or metabolic dysregulation.

  Top References

  • Effectiveness of niacin supplementation for patients with type 2 diabetes
  • Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials.
  • Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes
  • Postprandial triglyceride responses to aerobic exercise and extended-release niacin.

• Vitamin B6(Vitamin B-6 (Form: as Pyridoxine HCl))

  50 mg

  Ingredient research · Vitamin B6

  Vitamin B6 is an essential nutrient that helps enzymes process amino acids and supports neurotransmitter, hemoglobin, and immune function. Supplementation reliably corrects deficiency and can reduce nausea during pregnancy; outside these uses, it is most relevant when intake or absorption is inadequate.

  • Supports depressive-symptom measures in premenopausal women with hormone-related contexts.

  Top References

  • The role for vitamin B-6 as treatment for depression: a systematic review.
  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial

• Folic Acid

  400 mcg

  Ingredient research · Folic Acid

  Folic Acid is the synthetic, stable form of vitamin B9, needed for DNA synthesis, cell division, and healthy red blood cell formation. Supplementation reliably prevents or corrects folate deficiency and, when taken before conception and during early pregnancy, substantially lowers the risk of neural tube defects.

  • Supports folate status in women of reproductive age.
  • Supports healthy homocysteine levels.
  • Supports first-stroke prevention in adults with hypertension.
  • Supports endothelial-function measures in coronary artery disease.
  • Supports antidepressant response as an adjunct to fluoxetine, particularly in women.

  Top References

  • Folate Status of Reproductive Age Women and Neural Tube Defect Risk: The Effect of Long-Term Folic Acid Supplementation at Doses of 140 µg and 400 µg per Day
  • Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial.
  • Weekly iron–folic acid supplements containing 2.8 mg folic acid are associated with a lower risk of neural tube defects than the current practice of 0.4 mg: a randomised controlled trial in Malaysia
  • Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease.
  • Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial.
  • Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials
  • Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial.
  • Efficacy of folic acid supplementation on endothelial function and plasma homocysteine concentration in coronary artery disease: A meta-analysis of randomized controlled trials
  • Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.

• Vitamin B12(Vitamin B-12 (Form: as Cyanocobalamin))

  50 mcg

  Ingredient research · Vitamin B12

  Vitamin B12 is an essential nutrient needed for red blood cell formation, DNA synthesis, and normal nerve function. Supplementation reliably prevents or corrects deficiency—especially when intake or absorption is limited—and may improve anemia, fatigue, or neurologic symptoms caused by low B12, but is not a general energy booster when status is adequate.

  • Supports vitamin B12 status and responsive deficiency markers in low-status populations, including maternal and breast-milk status during pregnancy and early lactation.

  Top References

  • Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.
  • A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
  • Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status.

• Biotin

  50 mcg

  Ingredient research · Biotin

  Biotin is an essential B vitamin that helps enzymes process fats, carbohydrates, and amino acids. Supplementation reliably prevents or corrects deficiency, but extra biotin has not been shown to improve hair, skin, or nails in most people who are not deficient, and high intakes can distort certain laboratory test results.

• Pantothenic Acid(Pantothenic Acid (Form: as D-Calcium Pantothenate))

  50 mg

  Ingredient research · Vitamin B5

  Vitamin B5 is an essential nutrient used to make coenzyme A, a molecule central to releasing energy from food and building and breaking down fats. Supplementation prevents or corrects deficiency, but deficiency is uncommon and taking extra pantothenic acid has no clearly established benefit for most otherwise well-nourished people.

• PABA

  50 mg

  Ingredient research · PABA

  PABA is a compound bacteria use to make folate, but it is not a vitamin or essential nutrient for humans. Supplements are promoted mainly for skin and hair pigmentation, including reversing gray hair, though these benefits are not established; topical PABA has also been used as a UVB-filtering sunscreen ingredient.

• Choline Bitartrate

  50 mg

  Ingredient research · Choline Bitartrate

  Choline Bitartrate is a salt that supplies choline, an essential nutrient used to build cell membranes, make acetylcholine, and support normal liver function. It can help fill dietary gaps, but it is not clearly superior to other choline forms for cognitive effects despite often being sold for brain support.

• Inositol

  50 mg

  Ingredient research · Inositol

  Inositol is a vitamin-like carbohydrate that helps form cell membranes and relay insulin and other cellular signals. Supplementation, most often with myo-inositol or D-chiro-inositol, may improve insulin sensitivity and support more regular ovulation and menstrual cycles in people with polycystic ovary syndrome; effects can depend on the form and context.

  • Supports triglyceride markers.
  • Supports pregnancy-induced-hypertension incidence.

  Top References

  • Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study
  • Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes – a randomized and open-label, placebo-controlled clinical trial

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