NAC 600 mg

• N-Acetyl-L-Cysteine(Free-Form)

  600 mg

  Ingredient research · NAC

  NAC is a cysteine derivative that helps replenish glutathione, a major cellular antioxidant, and also thins mucus by breaking bonds in its proteins. As a supplement, it may support antioxidant defenses and respiratory health; acetylcysteine also has established medical uses as a mucolytic and as an antidote for acetaminophen poisoning.

  • Supports glutathione and antioxidant-defense measures.
  • Supports depressive symptoms and negative symptoms of schizophrenia.
  • Supports cannabis-use, craving, and abstinence outcomes.
  • Evidence supports kidney-function and injury-marker outcomes in clinical treatment settings.
  • Supports hearing-loss and ototoxicity outcomes in noise- and medication-exposure settings.

  Top References

  • N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study
  • Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status.
  • N‐acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double‐blind controlled trial in healthy subjects
  • Meta-analysis of randomised controlled trials with N-acetylcysteine in the treatment of schizophrenia
  • N‐acetylcysteine for depression and glutamate changes in the left prefrontal cortex in adolescents and young adults at risk for bipolar disorder: A pilot study
  • N-acetyl cysteine in the treatment of cannabis use disorder: A systematic review of clinical trials.
  • A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.
  • N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis
  • A double-blinded, placebo-controlled, multicenter clinical trial of N-acetylcysteine for preventing amphotericin B-induced nephrotoxicity
  • A systematic review and meta-analysis of the efficacy and safety of N-acetylcysteine in preventing aminoglycoside-induced ototoxicity: implications for the treatment of multidrug-resistant TB
  • Protective effects of vitamins/antioxidants on occupational noise‐induced hearing loss: A systematic review
  • Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial

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