Best-Rest Formula

• Vitamin B6(Vitamin B6 (Form: as Pyridoxal 5' Phosphate (Form: activated B6)))

  3.3 mg

  Ingredient research · Vitamin B6

  Vitamin B6 is an essential nutrient that helps enzymes process amino acids and supports neurotransmitter, hemoglobin, and immune function. Supplementation reliably corrects deficiency and can reduce nausea during pregnancy; outside these uses, it is most relevant when intake or absorption is inadequate.

  • Supports depressive-symptom measures in premenopausal women with hormone-related contexts.

  Top References

  • The role for vitamin B-6 as treatment for depression: a systematic review.
  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial

• Melatonin

  1 mg

  Ingredient research · Melatonin

  Melatonin is a hormone that signals biological night and helps synchronize the sleep–wake cycle, rather than acting simply as a sedative. Supplementation can shorten the time it takes to fall asleep and is especially useful for shifting circadian timing, such as with jet lag, though sleep-maintenance benefits are less consistent.

  • Supports sleep-onset outcomes.
  • Supports sleep quality, duration, efficiency, and continuity through the night.

  Top References

  • Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?
  • Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
  • Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial

• GABA

  300 mg

  Ingredient research · GABA

  GABA is the brain’s main inhibitory signaling molecule, helping dampen neural activity, and supplemental GABA is commonly taken to promote relaxation, ease stress, or support sleep. However, it is unclear how much orally consumed GABA reaches the brain, and human benefits appear modest and inconsistent.

• L-Theanine

  50 mg

  Ingredient research · L-Theanine

  L-Theanine is an amino acid found naturally in tea that can promote a calmer mental state without causing marked drowsiness. As a supplement, it may ease perceived stress, support sleep quality, and improve attention when paired with caffeine, although cognitive effects on its own are less consistent.

  • Supports selected stress and anxiety-related measures.

  Top References

  • The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review

• Valerian (Valeriana officinalis) extract(Valerian (Valeriana officinalis) extract (Form: standardized to contain 0.8% Valerenic Acids) PlantPart: root Genus: Valeriana Species: officinalis)

  400 mg

• Lemon Balm (Melissa officinalis) extract(Lemon Balm (Melissa officinalis) extract (Form: standardized to contain 5% Rosmarinic Acid) PlantPart: leaf Genus: Melissa Species: officinalis)

  150 mg

• Hops (Humulus lupulus) extract

  150 mg

• Passionflower (Passiflora incarnata) extract(Passionflower (Passiflora incarnata) extract (Form: standardized to contain 3.5% Vitexins) PlantPart: aerial parts Genus: Passiflora Species: incarnata)

  100 mg

• Chamomile (Matricaria recutita) extract

  100 mg

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