5-HTP Plus

• Vitamin B6

  1.7 mg

  Ingredient research · Vitamin B6

  Vitamin B6 is an essential nutrient that helps enzymes process amino acids and supports neurotransmitter, hemoglobin, and immune function. Supplementation reliably corrects deficiency and can reduce nausea during pregnancy; outside these uses, it is most relevant when intake or absorption is inadequate.

  • Supports depressive-symptom measures in premenopausal women with hormone-related contexts.

  Top References

  • The role for vitamin B-6 as treatment for depression: a systematic review.
  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial

• Vitamin B12

  2.4 mcg

  Ingredient research · Vitamin B12

  Vitamin B12 is an essential nutrient needed for red blood cell formation, DNA synthesis, and normal nerve function. Supplementation reliably prevents or corrects deficiency—especially when intake or absorption is limited—and may improve anemia, fatigue, or neurologic symptoms caused by low B12, but is not a general energy booster when status is adequate.

  • Supports vitamin B12 status and responsive deficiency markers in low-status populations, including maternal and breast-milk status during pregnancy and early lactation.

  Top References

  • Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.
  • A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
  • Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status.

• Calcium

  31 mg

  Ingredient research · Calcium

  Calcium is an essential mineral that gives bones and teeth their structure and also enables muscle contraction and nerve signaling. Supplements are most useful for filling inadequate intake and, often alongside vitamin D, can help preserve bone mineral density and support fracture prevention in some higher-risk groups.

  • Supports bone-mineral-density outcomes in studied healthy children and older women.

  Top References

  • Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials
  • The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial

• Magnesium

  5 mg

  Ingredient research · Magnesium

  Magnesium is an essential mineral that enables normal muscle and nerve function, energy production, heart rhythm, and bone maintenance. Supplements can correct low magnesium status and, depending on the formulation, may also help with constipation, muscle cramps, or migraine prevention in some people.

• L-5-Hydroxytryptophan

  100 mg

  Ingredient research · 5-HTP

  5-HTP is an amino acid derivative the body uses to make serotonin and, downstream, melatonin. It is commonly taken for mood and sleep, with possible but inconsistent benefits; because it raises serotonin, it can interact importantly with antidepressants and other serotonergic drugs.

  • Supports levodopa-induced motor-complication measures in Parkinson's disease.

  Top References

  • Efficacy and safety of 5-Hydroxytryptophan on levodopa-induced motor complications in Parkinson's disease: A preliminary finding

• Inositol

  500 mcg

  Ingredient research · Inositol

  Inositol is a vitamin-like carbohydrate that helps form cell membranes and relay insulin and other cellular signals. Supplementation, most often with myo-inositol or D-chiro-inositol, may improve insulin sensitivity and support more regular ovulation and menstrual cycles in people with polycystic ovary syndrome; effects can depend on the form and context.

  • Supports triglyceride markers.
  • Supports pregnancy-induced-hypertension incidence.

  Top References

  • Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study
  • Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes – a randomized and open-label, placebo-controlled clinical trial

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