Vitamin K for kidney transplant organ recipients: investigating vessel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial
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Interventional (Human) Studies
84
Enhanced Details
Methods
Single-centre, phase II, parallel-group, randomised, double-blind, placebo-controlled trial with 90 adult renal transplant recipients having a functioning transplant for more than 1 year.
Intervention
Randomised controlled trial assessing the effect of vitamin K supplementation on vascular stiffness and calcification in renal transplant recipients.
Results
The trial is designed to determine whether vitamin K supplementation improves vascular health markers in this population, potentially reducing cardiovascular risks.
Limitations
Participants on warfarin or with certain medical conditions were excluded, which may limit generalizability.
Abstract
Background Renal transplant recipients (RTRs) exhibit increased vascular stiffness and calcification; these parameters are associated with increased cardiovascular risk. Activity of endogenous calcification inhibitors such as matrix gla protein (MGP)...