Research paper
Vitamin K for kidney transplant organ recipients: investigating vessel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial
Citations: 8
Influential: 0
Interventional (Human) Studies
84
Study answer
What this study found
The trial is designed to determine whether vitamin K supplementation improves vascular health markers in this population, potentially reducing cardiovascular risks.
- Study & population
- Single-centre, phase II, parallel-group, randomised, double-blind, placebo-controlled trial with 90 adult renal transplant recipients having a functioning transplant for more than 1 year.
- Intervention
- Randomised controlled trial assessing the effect of vitamin K supplementation on vascular stiffness and calcification in renal transplant recipients.
- Key limitation
- Participants on warfarin or with certain medical conditions were excluded, which may limit generalizability.
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Open PDFOriginal abstract
Background Renal transplant recipients (RTRs) exhibit increased vascular stiffness and calcification; these parameters are associated with increased cardiovascular risk. Activity of endogenous calcification inhibitors such as matrix gla protein (MGP)…