Therapeutic effects of dietary antioxidative supplements on the management of type 2 diabetes and its complications; umbrella review of observational/trials meta-analysis studies

What this study found

Overall, dietary antioxidative supplements appeared potentially beneficial for glycemic control and some diabetes complications, but the evidence was heterogeneous and inconsistent across meta-analyses. Chromium was associated with significant reductions in FBS, HbA1c, and TGs, and zinc with reductions in FBS, FI, HbA1c, HOMA index, TC, LDL-C, and hs-CRP. Alpha-lipoic acid improved diabetic neuropathy symptoms after 14, 21, or 28 days at 300 mg/day or 600 mg/day, and vitamin D was linked to improvements in FBS, HbA1c, HOMA index, and inflammatory and oxidative stress biomarkers. CoQ10…

Study & population

Umbrella review of observational-study and clinical-trial meta-analyses published through June 2021.

Intervention

This umbrella review synthesized meta-analyses of multiple antioxidative supplement interventions rather than testing one regimen.

Key limitation

This is an umbrella review of meta-analyses, so conclusions inherit the limitations of the underlying studies.

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