Research paper
The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: a randomized clinical trial
Study answer
What this study found
The combination of probiotics plus dietary fiber produced the clearest benefit, significantly reducing weight and BMI and lowering total cholesterol versus probiotics alone, dietary fiber alone, or placebo. It also helped prevent deterioration in insulin resistance and other metabolic measures, while probiotics alone or dietary fiber alone helped prevent further weight gain. The intervention was considered safe, and constipation was more frequent in placebo after excluding constipation from the adverse-event comparison. Increased gut microbiota richness with the combined treatment was…
- Study & population
- Double-blind, randomized clinical trial conducted in China in adults with schizophrenia or bipolar disorder who were taking stable atypical antipsychotics and had antipsychotic-associated weight gain greater than 10%.
- Intervention
- Adults received oral probiotics, dietary fiber, or both for 12 weeks.
- Key limitation
- The active arms were relatively small, with 32 participants in the combination group and 29 in each single-intervention group, and follow-up lasted only 12 weeks.
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Open PDFOriginal abstract
Probiotics plus dietary fiber has demonstrated efficacy in improving metabolic abnormalities. However, the efficacy of probiotics and dietary fiber as well as their association with microbiota in attenuating antipsychotic-induced weight gain and meta…