Prenatal choline supplementation improves child sustained attention: A 7‐year follow‐up of a randomized controlled feeding trial

Study answer

What this study found

Numerous rodent studies demonstrate developmental programming of offspring cognition by maternal choline intake, with prenatal choline deprivation causing lasting adverse effects and supplemental choline producing lasting benefits. Few human studies have evaluated the effect of maternal choline supplementation on offspring cognition, with none following children to school age. Here, we report results from a controlled feeding study in which pregnant women were randomized to consume 480 mg choline/d (approximately the Adequate Intake [AI]) or 930 mg choline/d during the 3rd trimester.…

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Study & population

Interventional (Human) Studies

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Original abstract