Research paper
Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group.
- R. Holloway
- I. Shoulson
- K. Kieburtz
- M. Mcdermott
- P. Tariot
- Cornelia L. Kamp
- D. Day
- A. Shinaman
- S. Fahn
- A. Lang
- K. Marek
- J. Seibyl
- W. Weiner
- M. Welsh
- R. Pahwa
- S. Coe
- L. Barclay
- L. Sutherland
- K. Hildebrand
- J. Hubble
- C. Weeks
- P. LeWitt
- J. Miyasaki
- J. Duff
- E. Sime
- O. Suchowersky
- M. Stacy
- M. Kurth
- M. Brewer
- M. Harrigan
- D. Russell
- B. Fussell
- B. Ford
- S. Dillon
- J. Hammerstad
- C. Stone
- D. Riley
- P. Rainey
- D. Standaert
- M. Tennis
- F. Wooten
- E. Rost-ruffner
- S. Factor
- D. Brown
- J. Jankovic
- F. Atassi
- R. Kurlan
- I. Gardiner
- M. Panisset
- D. Amyot
- J. Hall
- A. Rajput
- T. Shirley
- R. Rodnitzky
- J. Dobson
- C. Shults
- D. Fontaine
- C. Waters
- S. Schuman
- R. Pfeiffer
- Shirley A. Rast
- B. Pfeiffer
- A. Brocht
- C. Casaceli
- S. Daigneault
- K. Hodgeman
- K. Honsinger
- C. O'Connell
- A. Watts
Study answer
What this study found
CONTEXT Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies have compared long-term outcomes after initiating dopaminergic therapy with pramipexole vs levodopa. OBJECTIVE To compare the development of dopaminergic motor complications after initial treatment of early PD with pramipexole vs levodopa. DESIGN Multicenter, parallel-group, double-blind, randomized controlled trial. SETTING Academic movement disorders clinics at 22 sites in the United States and Canada. PATIENTS Three hundred one patients with early PD who required…
A separate results summary is not available, so this answer uses the paper abstract.
- Study & population
- Interventional (Human) Studies
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Open PDFOriginal abstract
CONTEXT Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies have compared long-term outcomes after initiating dopaminergic therapy with pramipexole vs levodopa. OBJECTIVE To compare t…