Effects of probiotic, cinnamon, and synbiotic supplementation on glycemic control and antioxidant status in people with type 2 diabetes; a randomized, double-blind, placebo-controlled study

What this study found

Overall, probiotic, cinnamon, and synbiotic supplementation improved glycemic control, with no clear superiority for glucose outcomes, while the probiotic regimen showed the strongest antioxidant effects. Fasting blood glucose fell versus control with probiotic (P = 0.001) and synbiotic (P = 0.001), but cinnamon did not clearly differ from control (P = 0.063). HbA1c decreased in all three groups versus control: probiotic (P = 0.001), cinnamon (P = 0.001), and synbiotic (P = 0.04). Antioxidant enzyme activity improved modestly, especially with probiotic supplementation, including CAT (P <…

Study & population

Randomized, double-blind, placebo-controlled trial in Iranian adults with type 2 diabetes who were not using insulin and remained on usual pharmacotherapy.

Intervention

Participants received one of three capsule regimens for 3 months: Lactobacillus acidophilus 10^8 cfu daily, powdered cinnamon 0.5 g daily, or a synbiotic capsule combining Lactobacillus acidophilus 10^8 cfu with 0.5 g cinnamon daily.

Key limitation

The intervention period was short at 3 months, so durability of effects is uncertain.

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