Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
What this study found
Coenzyme Q10 showed modest benefits for glycemic control and HDL-C, but not for several other metabolic outcomes. Pooled analysis found reductions in HbA1c (WMD -0.29; 95% CI -0.54, -0.03; P = 0.03) and fasting blood glucose (WMD -11.21; 95% CI -18.99, -3.43; P = 0.005), while fasting insulin was not significant (WMD -0.48; 95% CI -2.54, 1.57; P = 0.65) and HOMA-IR was also not significant (MD -0.89; 95% CI -2.25, 0.48; P = 0.20). HDL-C increased (WMD 3.53; 95% CI 0.35, 6.71; P = 0.03), triglycerides showed a non-significant downward trend (WMD -16.50; 95% CI -35.66, 2.65; P = 0.09), and no…
- Study & population
- Systematic review and meta-analysis of randomized controlled trials in adults with type 2 diabetes mellitus.
- Intervention
- Oral coenzyme Q10 was evaluated across 16 randomized trials in adults with type 2 diabetes mellitus, most commonly at 200 mg/day; one trial used 100 mg/day.
- Key limitation
- The evidence base was limited by small sample sizes, short treatment durations, and high heterogeneity.
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Open PDFOriginal abstract
Objective To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD42018088474. The primary outcomes included glycosylated hemoglobin, fasting blood glucose, and fasting insulin. Result Thirteen trials involving 765 patients were included. Compared with the control group, coenzyme Q10 may decrease the HbA1c (WMD −0.29; 95% CI −0.54, −0.03; P = 0.03) and the fasting blood glucose (WMD −11.21; 95% CI −18.99, −3.43; P = 0.005). For fasting insulin, there is also not strong evidence that confirms which one is better because there was no statistical difference (WMD −0.48; 95% CI −2.54, 1.57; P = 0.65). Conclusion Based on current evidence, coenzyme Q10 may assist glycemic control, decrease TG, and improve HDL-C in patients with T2DM.