Research paper
Effect of Teriparatide on Bone Remodeling and Density in Premenopausal Idiopathic Osteoporosis: A Phase II Trial.
Study answer
What this study found
CONTEXT Premenopausal women with idiopathic osteoporosis (IOP) have abnormal skeletal microarchitecture and variable tissue-level bone formation rate (BFR). OBJECTIVES Compare 6 months (M) of teriparatide versus placebo on areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA), bone turnover markers (BTMs) and BFR at 3M by quadruple-labeled transiliac biopsy. Characterize 12M and 24M effects of teriparatide on aBMD and whether BTMs and BFR predict response. DESIGN 6M phase 2 randomized controlled trial (RCT) followed by open extension. SETTING Tertiary referral centers.…
A separate results summary is not available, so this answer uses the paper abstract.
- Study & population
- Interventional (Human) Studies
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Open PDFOriginal abstract
CONTEXT Premenopausal women with idiopathic osteoporosis (IOP) have abnormal skeletal microarchitecture and variable tissue-level bone formation rate (BFR). OBJECTIVES Compare 6 months (M) of teriparatide versus placebo on areal bone mineral density …