Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study
What this study found
The collagen peptide supplement improved stratum corneum hydration and skin elasticity versus standard hospital meals. In the intervention arm, stratum corneum hydration increased from 43.7 at baseline to 51.7 at week 8 (P = .001), and the between-group difference in change at week 8 was 8.0 (95% CI, 3.4 to 12.6; P = .001). Skin elasticity (R2) also favored supplementation, with between-group differences in change reaching 0.06 at week 6 (95% CI, 0.01 to 0.11; P = .026) and week 8 (95% CI, 0.00 to 0.11; P = .049). No adverse effects or events were reported.
- Study & population
- Multicenter open-label randomized controlled study in inpatients aged 65 years or older in convalescent rehabilitation wards in Japan.
- Intervention
- Participants in the active arm received 10.0 g/day of collagen peptides in an oral nutrition supplement (V CRESC CP10) by mouth once daily for 8 weeks, alongside standard hospital meals, compared with standard hospital meals alone.
- Key limitation
- Small active-arm sample size and only 8 weeks of follow-up limit precision and long-term inference.
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Open PDFOriginal abstract
ABSTRACT OBJECTIVE The purpose of this randomized open-label study was to investigate the effect of an oral nutrition supplement containing collagen peptides on stratum corneum hydration and skin elasticity. METHODS The study protocol was registered at the UMIN Clinical Trials Registry (UMIN 000027347). Once-a-day oral administration of a nutrition supplement containing collagen peptides (10.0 g) was instituted in 39 inpatients 65 years or older who were assigned to either the intervention or the control group using a block-randomization design. Stratum corneum hydration and skin elasticity were measured at baseline and at 2, 4, 6, and 8 weeks after the start of the intervention. RESULTS Mean stratum corneum hydration was significantly increased from 43.7 at baseline to 51.7 at postintervention week 8 in the intervention group (P = .001). Differences in skin elasticity from baseline were significant at postintervention week 6 (P = .026) and week 8 (P = .049). CONCLUSIONS Oral nutrition supplements containing collagen peptides may reduce skin vulnerability in older adults and thus prevent conditions such as skin tears.