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Research paper

Early fortification of human milk versus late fortification to promote growth in preterm infants.

The Cochrane database of systematic reviews
Q1
Aug 2019
Citations: 44
Influential: 3
Systematic Reviews / Meta-Analyses
93

Study answer

What this study found

BACKGROUND Uncertainty exists about the optimal point at which multi-component fortifier should be added to human milk for promoting growth in preterm infants. The most common practice is to start fortification when the infant's daily enteral feed volume reaches 100 mL/kg body weight. Another approach is to commence fortification earlier, in some cases as early as the first enteral feed. Early fortification of human milk could increase nutrient intake and growth rates but may increase the risk of feed intolerance and necrotising enterocolitis (NEC). OBJECTIVES To assess effects on growth and…

A separate results summary is not available, so this answer uses the paper abstract.

Study & population
Systematic Reviews / Meta-Analyses

Original abstract

BACKGROUND Uncertainty exists about the optimal point at which multi-component fortifier should be added to human milk for promoting growth in preterm infants. The most common practice is to start fortification when the infant's daily enteral feed vo…