Research paper
Caffeine for apnea and prevention of neurodevelopmental impairment in preterm infants: systematic review and meta-analysis
Study answer
What this study found
This systematic review and meta-analysis evaluated the evidence for dose and effectiveness of caffeine in preterm infants. MEDLINE, EMBASE, CINHAL Plus, CENTRAL, and trial databases were searched to July 2022 for trials randomizing preterm infants to caffeine vs. placebo/no treatment, or low (≤10 mg·kg−1) vs. high dose (>10 mg·kg−1 caffeine citrate equivalent). Two researchers extracted data and assessed risk of bias using RoB; GRADE evaluation was completed by all authors. Meta-analysis of 15 studies (3530 infants) was performed in REVMAN across four epochs: neonatal/infant (birth-1 year),…
A separate results summary is not available, so this answer uses the paper abstract.
- Study & population
- Systematic Reviews / Meta-Analyses
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Open PDFOriginal abstract
This systematic review and meta-analysis evaluated the evidence for dose and effectiveness of caffeine in preterm infants. MEDLINE, EMBASE, CINHAL Plus, CENTRAL, and trial databases were searched to July 2022 for trials randomizing preterm infants to…