Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.

Included randomised controlled trials with participants having AMD in one or both eyes, assessing visual acuity and disease progression.

Assessment of the effects of antioxidant vitamin or mineral supplementation on the progression of age-related macular degeneration (AMD).

Antioxidant vitamin and mineral supplementation may have a modest effect in delaying the progression of AMD, especially noted in the AREDS trial, but other smaller trials showed little consistent benefit.

The evidence mainly comes from one large trial, and the effectiveness of supplementation may vary by population and AMD stage.