A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis
What this study found
Garlic supplementation improved oxidative stress markers and quality of life versus placebo over 8 weeks. Total antioxidant capacity increased from 308 ± 16.63 to 334.60 ± 13.72, with between-group P1 = 0.032 and ANCOVA P = 0.02, while malondialdehyde decreased from 3.55 ± 1.99 to 2.73 ± 1.27, with between-group P1 = 0.017 and ANCOVA P < 0.001. Health Assessment Questionnaire scores improved and were better than placebo at the end of treatment (between-groups P = 0.026; ANCOVA P < 0.001), and pain after activity was lower in the garlic group than placebo (P < 0.001). The intervention was…
- Study & population
- Randomized, double-blind, placebo-controlled clinical trial in women with active rheumatoid arthritis (DAS-28 > 3.2) receiving DMARDs.
- Intervention
- The active arm received 500 mg garlic tablets orally twice daily for 8 weeks, compared with placebo.
- Key limitation
- The trial was small, single-center, and short in duration, which limits confidence in durability and generalizability.
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Open PDFOriginal abstract
Rheumatoid arthritis (RA), is a prevalent immune‐inflammatory disease, which is associated with disabling pain. Oxidative stress might play a role in RA pathogenesis and outcomes. According to the antioxidant properties of garlic, the current study was performed to evaluate the garlic supplement effects on some serum levels of oxidative stress biomarkers, and quality of life in patients with rheumatoid arthritis.