B-Stress Formula

• Vitamin C

  250 mg

  Ingredient research · Vitamin C

  Vitamin C is an essential water-soluble nutrient that supports collagen production, antioxidant defenses, and the normal function of immune cells. Supplementation reliably prevents or corrects deficiency, can improve absorption of plant-based iron, and may modestly shorten the duration of common colds when taken regularly.

  • Supports lower common-cold risk during brief periods of severe physical exercise or cold stress.
  • Supports circulating Vitamin C status across studied healthy and clinical populations.
  • Supports short-term blood-pressure and endothelial-function outcomes in studied adults.
  • Supports fasting-glucose and HbA1c outcomes in adults with type 2 diabetes.

  Top References

  • Vitamin C for preventing and treating the common cold.
  • Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review
  • High-dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males.
  • Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials.
  • Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials
  • Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
  • Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial
  • Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

• Thiamine

  25 mg

  Ingredient research · Thiamine

  Thiamine is vitamin B1, an essential nutrient that helps convert carbohydrates into usable energy and supports normal nerve and heart function. Supplementation reliably prevents or corrects deficiency, with particular relevance when absorption or intake is impaired, including in chronic heavy alcohol use.

  • Supports depression-treatment response when used alongside standard antidepressant treatment.

  Top References

  • Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial

• Riboflavin

  25 mg

  Ingredient research · Vitamin B2

  Vitamin B2 is riboflavin, an essential nutrient that helps enzymes release energy from food and supports normal red blood cell, skin, and nervous-system function. Supplementation reliably prevents or corrects deficiency, and regular use can reduce migraine frequency and severity in some people.

  • Supports blood-pressure control in treated hypertensive adults with the MTHFR 677TT genotype.

  Top References

  • Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.
  • Blood Pressure in Treated Hypertensive Individuals With the MTHFR 677TT Genotype Is Responsive to Intervention With Riboflavin: Findings of a Targeted Randomized Trial

• Niacin

  62.5 mg

  Ingredient research · Niacin

  Niacin is vitamin B3, essential for enzymes that convert food into energy and support normal skin and nervous-system function. Supplementation prevents or corrects deficiency; in high-dose nicotinic acid form it can alter cholesterol and triglycerides, but this pharmacologic use is distinct from routine nutritional supplementation.

  • Supports favorable changes in selected cholesterol fractions, including LDL, HDL, and total cholesterol, in studied metabolic and diabetes populations.
  • Supports favorable fasting-triglyceride changes in studied adults with diabetes or metabolic dysregulation.

  Top References

  • Effectiveness of niacin supplementation for patients with type 2 diabetes
  • Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials.
  • Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes
  • Postprandial triglyceride responses to aerobic exercise and extended-release niacin.

• Vitamin B6

  50 mg

  Ingredient research · Vitamin B6

  Vitamin B6 is an essential nutrient that helps enzymes process amino acids and supports neurotransmitter, hemoglobin, and immune function. Supplementation reliably corrects deficiency and can reduce nausea during pregnancy; outside these uses, it is most relevant when intake or absorption is inadequate.

  • Supports depressive-symptom measures in premenopausal women with hormone-related contexts.

  Top References

  • The role for vitamin B-6 as treatment for depression: a systematic review.
  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial

• Folate

  From 200 mcg Folic Acid

  333 mcg DFE

  Ingredient research · Folate

  Folate is vitamin B9, an essential nutrient needed for DNA synthesis, cell division, and healthy red blood cell formation. Supplementation is especially important before conception and in early pregnancy because adequate folate reliably reduces neural tube defect risk, and it can also correct folate-deficiency anemia.

  • Supports homocysteine measures in women with PCOS and adults with metabolic syndrome.
  • Supports insulin and beta-cell-function markers in women with PCOS or cervical intraepithelial neoplasia.
  • Supports selected lipid-panel and vascular markers in women with PCOS and adults with metabolic syndrome.
  • Supports selected inflammation and oxidative-stress biomarkers in PCOS, metabolic syndrome, or cervical intraepithelial neoplasia.

  Top References

  • The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled clinical trial
  • Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.
  • The Effects of Folate Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Patients with Metabolic Syndrome
  • Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial.

• Vitamin B12

  50 mcg

  Ingredient research · Vitamin B12

  Vitamin B12 is an essential nutrient needed for red blood cell formation, DNA synthesis, and normal nerve function. Supplementation reliably prevents or corrects deficiency—especially when intake or absorption is limited—and may improve anemia, fatigue, or neurologic symptoms caused by low B12, but is not a general energy booster when status is adequate.

  • Supports vitamin B12 status and responsive deficiency markers in low-status populations, including maternal and breast-milk status during pregnancy and early lactation.

  Top References

  • Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.
  • A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
  • Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status.

• Biotin

  150 mcg

  Ingredient research · Biotin

  Biotin is an essential B vitamin that helps enzymes process fats, carbohydrates, and amino acids. Supplementation reliably prevents or corrects deficiency, but extra biotin has not been shown to improve hair, skin, or nails in most people who are not deficient, and high intakes can distort certain laboratory test results.

• Pantothenic Acid

  75 mg

  Ingredient research · Vitamin B5

  Vitamin B5 is an essential nutrient used to make coenzyme A, a molecule central to releasing energy from food and building and breaking down fats. Supplementation prevents or corrects deficiency, but deficiency is uncommon and taking extra pantothenic acid has no clearly established benefit for most otherwise well-nourished people.

• Choline

  25 mg

  Ingredient research · Choline

  Choline is an essential nutrient used to build cell membranes, make the neurotransmitter acetylcholine, and transport fat from the liver. Supplementation can help meet needs when dietary intake is low, with particular relevance during pregnancy and for supporting normal liver, muscle, and nervous-system function.

• Eleuthero Root Extract

  125 mg

  Ingredient research · Siberian Ginseng Root

  Siberian Ginseng Root is the root of Eleutherococcus senticosus, an “adaptogenic” herb traditionally taken to improve resilience to physical or mental stress. It may modestly help fatigue or exercise capacity in some settings, but human findings are inconsistent; despite its name, it is not a Panax ginseng and should not inherit that herb’s claims.

• Inositol

  50 mg

  Ingredient research · Inositol

  Inositol is a vitamin-like carbohydrate that helps form cell membranes and relay insulin and other cellular signals. Supplementation, most often with myo-inositol or D-chiro-inositol, may improve insulin sensitivity and support more regular ovulation and menstrual cycles in people with polycystic ovary syndrome; effects can depend on the form and context.

  • Supports triglyceride markers.
  • Supports pregnancy-induced-hypertension incidence.

  Top References

  • Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study
  • Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes – a randomized and open-label, placebo-controlled clinical trial

• Para-Aminobenzoic Acid

  25 mg

  Ingredient research · PABA

  PABA is a compound bacteria use to make folate, but it is not a vitamin or essential nutrient for humans. Supplements are promoted mainly for skin and hair pigmentation, including reversing gray hair, though these benefits are not established; topical PABA has also been used as a UVB-filtering sunscreen ingredient.

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