Hemagenics

• Thiamine(Thiamin (Form: as Thiamin Mononitrate))

  5 mg

  Ingredient research · Thiamine

  Thiamine is vitamin B1, an essential nutrient that helps convert carbohydrates into usable energy and supports normal nerve and heart function. Supplementation reliably prevents or corrects deficiency, with particular relevance when absorption or intake is impaired, including in chronic heavy alcohol use.

  • Supports depression-treatment response when used alongside standard antidepressant treatment.

  Top References

  • Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial

• Vitamin B6(Vitamin B6 (Form: as Pyridoxine HCl))

  5 mg

  Ingredient research · Vitamin B6

  Vitamin B6 is an essential nutrient that helps enzymes process amino acids and supports neurotransmitter, hemoglobin, and immune function. Supplementation reliably corrects deficiency and can reduce nausea during pregnancy; outside these uses, it is most relevant when intake or absorption is inadequate.

  • Supports depressive-symptom measures in premenopausal women with hormone-related contexts.

  Top References

  • The role for vitamin B-6 as treatment for depression: a systematic review.
  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial

• Folate(Folate (Form: as Calcium L-5-Methyltetrahydrofolate (Alt. Name: Metafolin)) Note: As Metafolin)

  600 mcg

  Ingredient research · Folate

  Folate is vitamin B9, an essential nutrient needed for DNA synthesis, cell division, and healthy red blood cell formation. Supplementation is especially important before conception and in early pregnancy because adequate folate reliably reduces neural tube defect risk, and it can also correct folate-deficiency anemia.

  • Supports homocysteine measures in women with PCOS and adults with metabolic syndrome.
  • Supports insulin and beta-cell-function markers in women with PCOS or cervical intraepithelial neoplasia.
  • Supports selected lipid-panel and vascular markers in women with PCOS and adults with metabolic syndrome.
  • Supports selected inflammation and oxidative-stress biomarkers in PCOS, metabolic syndrome, or cervical intraepithelial neoplasia.

  Top References

  • The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled clinical trial
  • Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.
  • The Effects of Folate Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Patients with Metabolic Syndrome
  • Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial.

• Vitamin B12(Vitamin B12 (Form: as Methylcobalamin))

  350 mcg

  Ingredient research · Vitamin B12

  Vitamin B12 is an essential nutrient needed for red blood cell formation, DNA synthesis, and normal nerve function. Supplementation reliably prevents or corrects deficiency—especially when intake or absorption is limited—and may improve anemia, fatigue, or neurologic symptoms caused by low B12, but is not a general energy booster when status is adequate.

  • Supports vitamin B12 status and responsive deficiency markers in low-status populations, including maternal and breast-milk status during pregnancy and early lactation.

  Top References

  • Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.
  • A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
  • Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status.

• Calcium

  25 mg

  Ingredient research · Calcium

  Calcium is an essential mineral that gives bones and teeth their structure and also enables muscle contraction and nerve signaling. Supplements are most useful for filling inadequate intake and, often alongside vitamin D, can help preserve bone mineral density and support fracture prevention in some higher-risk groups.

  • Supports bone-mineral-density outcomes in studied healthy children and older women.

  Top References

  • Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials
  • The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial

• Iron(Iron (Form: as ferrous bis-glycinate))

  29 mg

  Ingredient research · Iron

  Iron is an essential mineral needed to make hemoglobin and carry oxygen throughout the body. Supplementation can reliably prevent or correct iron-deficiency anemia, helping restore energy, exercise capacity, and cognitive function when low iron is the cause; it is also commonly used when requirements rise, such as during pregnancy.

  • Supports hemoglobin and iron stores in menstruating women, especially when iron status is low.
  • Supports reduced subjective fatigue in iron-deficient adults without anemia.
  • Supports selected maximal and submaximal exercise-performance measures in women of reproductive age, particularly those who are iron-deficient or trained.
  • Supports selected attention and concentration outcomes in older children and women.

  Top References

  • Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
  • Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials
  • Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis.
  • The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis

• Phosphorus

  19 mg

  Ingredient research · Phosphorus

  Phosphorus is an essential dietary mineral that helps build bones and teeth and is integral to cellular energy, cell membranes, and acid–base balance. Supplements are mainly relevant when intake or absorption is inadequate; most diets already provide enough, and excess phosphorus can be problematic, especially with impaired kidney function.

• Copper(Copper (Form: as Copper Lysinate HCl))

  1 mg

  Ingredient research · Copper

  Copper is an essential trace mineral used by enzymes that support iron metabolism, connective-tissue formation, energy production, antioxidant defense, and nervous and immune function. Supplementation can correct low copper status and related anemia or neurologic problems, but extra copper offers no established benefit when intake and status are adequate.

• Succinic Acid

  100 mg

• Glycine

  100 mg

  Ingredient research · Glycine

  Glycine is a simple amino acid used to build proteins—especially collagen—and to make glutathione and other important molecules; it also acts as an inhibitory neurotransmitter. Supplementation may modestly improve sleep quality and next-day alertness, while proposed metabolic and connective-tissue benefits are less certain.

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