Vitamin B12 + Folic Acid
Brand Quality
Why this score
Testing practices
- Lot Tested
- Third-Party Lab Tested
- Transparent Batch-Specific COAs
- ISO 17025 Lab
Testing coverage
- Identity
- Purity
- Potency
- Heavy Metals
- Raw Ingredient Testing
Certifications
- NSF Certified
Manufacturing standards
- cGMP Certified
- Made in USA
Innovation
- Clinically Studied Product
Active Ingredients
- 400 mcg
Folate
Ingredient research · Folate
Folate is vitamin B9, an essential nutrient needed for DNA synthesis, cell division, and healthy red blood cell formation. Supplementation is especially important before conception and in early pregnancy because adequate folate reliably reduces neural tube defect risk, and it can also correct folate-deficiency anemia.
- Supports homocysteine measures in women with PCOS and adults with metabolic syndrome.
- Supports insulin and beta-cell-function markers in women with PCOS or cervical intraepithelial neoplasia.
- Supports selected lipid-panel and vascular markers in women with PCOS and adults with metabolic syndrome.
- Supports selected inflammation and oxidative-stress biomarkers in PCOS, metabolic syndrome, or cervical intraepithelial neoplasia.
Top References
- The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled clinical trial
- Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.
- The Effects of Folate Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Patients with Metabolic Syndrome
- Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial.
- 250 mcg
Vitamin B12
Ingredient research · Vitamin B12
Vitamin B12 is an essential nutrient needed for red blood cell formation, DNA synthesis, and normal nerve function. Supplementation reliably prevents or corrects deficiency—especially when intake or absorption is limited—and may improve anemia, fatigue, or neurologic symptoms caused by low B12, but is not a general energy booster when status is adequate.
- Supports vitamin B12 status and responsive deficiency markers in low-status populations, including maternal and breast-milk status during pregnancy and early lactation.
Top References
- Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.
- A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
- Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status.
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