Youth depression alleviation: the Fish Oil Youth Depression Study (YoDA‐F): A randomized, double‐blind, placebo‐controlled treatment trial
What this study found
US authorities have recommended ‘black‐box’ warnings for antidepressants because of the increased risk of suicidality for individuals up to age 25. There is thus a clinical and ethical imperative to provide effective treatment for youth depression with an acceptable risk–benefit balance. Long‐chain omega‐3 polyunsaturated fatty acids (PUFAs) play an important role in a range of physiological processes in living organisms. Supplementation with omega‐3 PUFAs has been shown to have a range of beneficial effects on both physical and mental health, and results of previous trials suggest that…
A separate results summary is not available, so this answer uses the paper abstract.
- Study & population
- Interventional (Human) Studies
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Open PDFOriginal abstract
US authorities have recommended ‘black‐box’ warnings for antidepressants because of the increased risk of suicidality for individuals up to age 25. There is thus a clinical and ethical imperative to provide effective treatment for youth depression with an acceptable risk–benefit balance. Long‐chain omega‐3 polyunsaturated fatty acids (PUFAs) play an important role in a range of physiological processes in living organisms. Supplementation with omega‐3 PUFAs has been shown to have a range of beneficial effects on both physical and mental health, and results of previous trials suggest that omega‐3 PUFAs may be a safe and effective treatment for depression. However, conclusions from these trials have been limited by their relatively small sample sizes.