Research paper
Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies.
The American journal of clinical nutrition
Q1
Citations: 198
Influential: 8
Systematic Reviews / Meta-Analyses
97
Study answer
What this study found
Whole-grain diets lowered total cholesterol and LDL cholesterol compared with non-whole-grain control diets, while HDL cholesterol and triglycerides were not significantly affected overall. The strongest cholesterol-lowering effect was seen with whole-grain oat products. Calorie-restricted background diets appeared to augment the cholesterol-lowering effect, and very high whole-grain doses did not provide extra benefit. Overall heterogeneity was generally low, but effects varied by grain type and data were limited for rye, barley, and rice.
- Study & population
- Systematic review and meta-analysis of 24 randomized controlled studies reporting 52 treatment arms in apparently healthy adults not taking statins.
- Intervention
- Active interventions were whole-grain foods or whole-grain diets compared with non-whole-grain control diets.
- Key limitation
- Arm-specific sample sizes were not consistently reported in the provided text, limiting precision about per-group power.
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