Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Study answer

What this study found

Adjunct antioxidant vitamin supplementation improved Helicobacter pylori eradication rates when added to standard therapy. The pooled effect favored supplementation for per-protocol eradication (RR 1.22; 95% CI 1.02-1.44) and intention-to-treat eradication (RR 1.25; 95% CI 1.06-1.47). The review also found that Helicobacter pylori infection is associated with lower serum levels of several vitamins, and eradication can restore those levels. Overall, the authors concluded that multivitamin or antioxidant vitamin supplementation may be advantageous in Helicobacter pylori-positive patients.

Study & population

Systematic review and meta-analysis of observational studies and randomized controlled trials from multiple countries.

Intervention

Adjunct antioxidant vitamin regimens were evaluated alongside standard Helicobacter pylori eradication therapy.

Key limitation

The evidence base was heterogeneous, combining observational studies and randomized trials across different countries and populations.

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Original abstract