Research paper

Vitamin D supplementation in obese type 2 diabetes subjects in Ajman, UAE: a randomized controlled double-blinded clinical trial

European Journal of Clinical Nutrition

Nov 2014

DOI: 10.1038/ejcn.2014.251

Citations: 82

Influential: 8

Interventional (Human) Studies

Study answer

What this study found

Vitamin D3 corrected vitamin D deficiency biochemically but did not improve glycemic control or lipids. Serum 25(OH)D increased by the end of phase 1 (P = 0.003), then fell in phase 2 (P o0.01) while remaining above baseline (P o0.01), and parathyroid hormone decreased in phase 2 in the vitamin D group (P = 0.003). In contrast, fasting glucose, HbA1c, C-peptide, creatinine, phosphorous, alkaline phosphatase, lipids, C-reactive protein, and thyroid-stimulating hormone did not change significantly in either group.

Study & population: Randomized, double-blind, placebo-controlled trial in obese, vitamin D-deficient Emirati adults with type 2 diabetes in Ajman, United Arab Emirates.
Intervention: Vitamin D3 was given as oral unlabelled capsules for 6 months: 6000 IU/day for the first 3 months, then 3000 IU/day for the next 3 months.
Key limitation: Modest sample size with attrition from randomization to analysis, limiting power for metabolic outcomes.

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