Research paper
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial
Study answer
What this study found
End-study 25(OH)D levels were higher with supplementation (800 IU/day: 82.5 nmol/L; 3200 IU/day: 105.4 nmol/L vs 53.6 nmol/L in controls). Breakthrough infection risk did not decrease (aHR 1.28 [0.89-1.84] for 800 IU/day; aHR 1.17 [0.81-1.70] for 3200 IU/day). IgGAM anti-Spike titres, neutralising antibody titres, and IFN-γ responses showed no inter-arm differences. Conclusion: Vitamin D replacement raises 25(OH)D but does not influence SARS-CoV-2 vaccine efficacy or immunogenicity; not recommended as an adjunct to vaccination in adults with suboptimal baseline vitamin D.
- Study & population
- Three sub-studies nested within the CORONAVIT randomized controlled trial.
- Intervention
- Vitamin D3 capsules; 800 IU/day or 3200 IU/day for 6 months; one capsule daily; mailed to participants; unsupervised usage.
- Key limitation
- Open-label design; baseline imbalance in pre-vaccination SARS-CoV-2 infection; randomisation not stratified by sub-study participation; no baseline 25(OH)D data for the no-offer arm; limited power to assess severe disease due to few hospitalizations.
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Open PDFOriginal abstract
Vitamin D deficiency has been reported to associate with the impaired development of antigen-specific responses following vaccination. We aimed to determine whether vitamin D supplements might boost the immunogenicity and efficacy of SARS-CoV-2 vacci…