Research paper
Vitamin D Supplementation and Prevention of Type 2 Diabetes.
- A. Pittas
- B. Dawson-Hughes
- Patricia R. Sheehan
- J. Ware
- W. Knowler
- V. Aroda
- Irwin Brodsky
- L. Ceglia
- C. Chadha
- Ranee Chatterjee
- C. Desouza
- R. Dolor
- J. Foreyt
- P. Fuss
- A. Ghazi
- D. Hsia
- K. Johnson
- S. Kashyap
- Sun Kim
- E. Leblanc
- M. Lewis
- E. Liao
- Lisa M. Neff
- J. Nelson
- Patrick O’Neil
- Jean Y. Park
- A. Peters
- L. Phillips
- R. Pratley
- P. Raskin
- N. Rasouli
- D. Robbins
- C. Rosen
- Ellen M. Vickery
- M. Staten
Citations: 525
Influential: 32
Interventional (Human) Studies
91
COI
Study answer
What this study found
Vitamin D3 did not significantly reduce progression to type 2 diabetes over a median follow-up of 2.5 years. New-onset diabetes occurred in 293 participants in the vitamin D group versus 323 in the placebo group, corresponding to 9.39 and 10.66 events per 100 person-years. The hazard ratio was 0.88 (95% CI, 0.75 to 1.04; P = 0.12). Adverse events did not differ significantly between groups.
- Study & population
- Randomized, placebo-controlled trial conducted at 22 academic medical centers in the United States.
- Intervention
- Vitamin D3 (cholecalciferol) was given orally as a 4000 IU soft-gel pill once daily during the trial.
- Key limitation
- Follow-up was only about 2.5 years, which may be too short to detect a modest prevention effect.
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Open PDFOriginal abstract
BACKGROUND Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin D supplementation lowers the risk of diabetes is unknown. METHODS We randomly assigned adu…