Research paper

Vitamin D status and dental caries in healthy Swedish children

Nutrition Journal

Jan 2018

DOI: 10.1186/s12937-018-0318-1

Citations: 71

Influential: 2

Observational Studies (Human)

Study answer

What this study found

Higher 25(OH)D status at age 6 was associated with lower odds of caries at age 8 (OR ≈ 0.96 per 1 nmol/L increase; p = 0.024) in the basic model, but the association weakened after adjusting for BMI and vitamin D supplement intake and was not significant after correction for small-sample bias. Similar results were observed using vitamin D status after the 3-month intervention. Enamel defects showed no association with vitamin D status. Vitamin D status was positively associated with saliva LL37 levels; caries presence was associated with higher LL37, suggesting a microbiota-related response.…

Study & population: Randomized controlled trial (DViSUM) in healthy Swedish children.
Intervention: Vitamin D3 in a milk-based supplement, taken daily for 3 months; dosing arms: 25 μg/day, 10 μg/day, or 2 μg/day (placebo).
Key limitation: Small dental-follow-up sample (n=85) with limited power; follow-up participants may not be representative of the original cohort; vitamin D status not repeatedly measured across the entire interval; potential response bias in questionnaires; study population selected for vitamin D supplementation in early life and…

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Original abstract

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