Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome

Study answer

What this study found

Vitamin D plus probiotic co-supplementation produced overall beneficial effects in women with PCOS over 12 weeks. Compared with placebo, it improved mental health outcomes, with significant between-group effects for BDI total score (β -0.58, 95% CI -1.15 to -0.02; P = 0.04), GHQ (β -0.93, 95% CI -1.78 to -0.08; P = 0.03), and DASS (β -0.90, 95% CI -1.67 to -0.13; P = 0.02), while PSQI was not significant (P = 0.28). It also reduced total testosterone (β -0.19, 95% CI -0.28 to -0.10; P < 0.001), mF-G scores (β -0.95, 95% CI -1.39 to -0.51; P < 0.001), hs-CRP (β -0.67, 95% CI -0.97 to -0.38; P…

Study & population

Randomized, placebo-controlled trial in women with polycystic ovary syndrome diagnosed by Rotterdam criteria.

Intervention

Women in the active arm received oral vitamin D 50,000 IU every 2 weeks plus an oral probiotic capsule providing 8 × 10^9 CFU/day for 12 weeks.

Key limitation

The active arm was small (n = 30), the intervention lasted only 12 weeks, and the trial was conducted at a single center, which limits generalizability.

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Original abstract