Research paper

Vitamin A intake and the risk of hip fracture in postmenopausal women: the Iowa Women’s Health Study

Osteoporosis International

Feb 2004

DOI: 10.1007/s00198-003-1577-y

Citations: 101

Influential: 10

Observational Studies (Human)

Study answer

What this study found

Supplement users had a 1.18-fold higher risk of incident hip fracture vs nonusers after adjustment (RR 1.18, 95% CI 0.99–1.41); no increased risk of all fractures (RR 1.00, 95% CI 0.95–1.05). No dose–response relationship for vitamin A or retinol from supplements; no association between total vitamin A or retinol intake and hip or all fractures. Among nonusers, higher intake of food-derived vitamin A was associated with fewer all fractures (p for trend = 0.01). Conclusion: little evidence that higher vitamin A or retinol intake increases hip or all fracture risk in this cohort; any observed…

Study & population: Prospective cohort study (Iowa Women's Health Study).
Intervention: Vitamin A-containing dietary supplements; baseline exposure; intake from supplements categorized as <5,000 IU, 5,000–9,999 IU, or ≥10,000 IU; taken orally; follow-up duration about 9.5 years.
Key limitation: Vitamin A intake measured only at baseline with a semiquantitative FFQ; high intraindividual variation and possible exposure misclassification; dietary changes over time not captured; fracture outcomes self-reported; inability to distinguish traumatic vs osteoporotic hip fractures; generalizability limited to…

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Original abstract

No abstract is available for this paper.