Research paper
Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial.
Study answer
What this study found
The concentrated 1.5 kcal/mL formula increased calorie delivery without increasing enteral intolerance. Daily calorie delivery was 1832 kcal/d versus 1259 kcal/d with the 1.0 kcal/mL formula (P < 0.001), and 89% versus 16% of study feeding days met estimated caloric requirements. Daily volume delivered was similar (1221 mL/d versus 1259 mL/d; P = 0.628), showing the benefit came from higher energy density rather than higher volume. Ninety-day mortality was 20% versus 37% (P = 0.057), but ICU, hospital, and 28-day mortality did not differ, and the trial was not powered to test mortality…
- Study & population
- Multicenter, randomized, double-blind trial in 5 Australian tertiary-referral ICUs.
- Intervention
- Critically ill adults received a concentrated enteral nutrition formula at 1.5 kcal/mL, delivered enterally at 1 mL/kg ideal body weight per hour, with a maximum rate of 100 mL/h.
- Key limitation
- The sample size was small and the study was not powered for mortality or other clinical outcomes.
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Open PDFOriginal abstract
BACKGROUND Critically ill patients typically receive ∼60% of estimated calorie requirements. OBJECTIVES We aimed to determine whether the substitution of a 1.5-kcal/mL enteral nutrition solution for a 1.0-kcal/mL solution resulted in greater calorie …