Treatment of vitamin D insufficiency in children and adolescents with inflammatory bowel disease: a randomized clinical trial comparing three regimens.

Study answer

What this study found

The more effective regimens for raising serum 25OHD over 6 weeks were vitamin D3 2,000 IU daily and vitamin D2 50,000 IU weekly; both outperformed vitamin D2 2,000 IU daily. Mean 25OHD increased by 9.3 ± 1.8 ng/mL with daily D2, 16.4 ± 2.0 ng/mL with daily D3, and 25.4 ± 2.5 ng/mL with weekly D2, with follow-up levels of 25.7 ± 2.2, 31.5 ± 1.9, and 40.8 ± 2.6 ng/mL, respectively. Vitamin D3 produced a greater rise than vitamin D2 at the same 2,000 IU daily dose, and 95% of participants in the daily D3 and weekly D2 arms exceeded 20 ng/mL versus 75% in the daily D2 arm. All regimens were safe…

Study & population

Randomized clinical trial in children and adolescents with inflammatory bowel disease and vitamin D insufficiency (serum 25OHD ≤ 20 ng/mL).

Intervention

Three oral vitamin D repletion regimens were compared over 6 weeks: vitamin D2 2,000 IU daily, vitamin D3 2,000 IU daily, and vitamin D2 50,000 IU weekly.

Key limitation

The trial was short and relatively small, with only 20 to 21 completers per arm, which limits precision for comparative efficacy and safety.

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Original abstract