Research paper

TOLLIP, MUC5B, and the Response to N-Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine

Dec 2015

DOI: 10.1164/rccm.201505-1010OC

Citations: 264

Influential: 7

Observational Studies (Human)

Study answer

What this study found

Significant genotype–treatment interaction between NAC and rs3750920 (TOLLIP). In PANTHER, NAC reduced composite endpoint risk in rs3750920 TT genotype (HR 0.14; 95% CI 0.02–0.83; P=0.03) and showed a non-significant trend toward higher risk in rs3750920 CC genotype (HR 3.23; 95% CI 0.79–13.16; P=0.10). Replication in INSPIRE/UChicago showed TT genotype with NAC linked to reduced risk (HR 0.23; 95% CI 0.06–0.93; P=0.04); CT and CC genotypes linked to increased risk (CT: HR 2.18; 95% CI 1.14–4.13; P=0.02; CC: HR 3.11; 95% CI 1.25–7.72; P=0.01). Authors conclude NAC may be efficacious for IPF…

Study & population: Post hoc exploratory analysis of IPFnet PANTHER-IPF trial (NCT00650091) with replication in INSPIRE and UChicago cohorts.
Intervention: N-acetylcysteine (NAC) therapy; dosage and duration not specified in provided text.
Key limitation: Post hoc exploratory analysis; not randomized by genotype, potential genotype-frequency bias; race/ethnicity self-reported; ~50% genetic-consent rate reducing power; small genotype-stratified event counts; replication cohorts had missing hospitalization data and potential disease-stage differences; results may not…

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Original abstract

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