The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies

Study answer

What this study found

Vitamin D deficiency was associated with a higher risk of atrial fibrillation and postoperative AF after CABG, while higher circulating vitamin D was associated with lower AF risk. In dose-response analyses, each 10 ng/mL increase in vitamin D was associated with a reduced risk of AF, with an inverse relationship and no strong evidence of nonlinearity for AF. For POAF, data were limited but suggested a protective effect. The association appeared stronger in adults aged 65 years or older, and the authors concluded that prospective and interventional studies are still needed to determine…

Study & population

Systematic review and dose-response meta-analysis of observational studies in adults from the general population and patients undergoing CABG, focused on the association between circulating 25(OH)D and atrial fibrillation risk.

Intervention

Vitamin D was evaluated as the active supplement exposure, with the only arm-level randomized detail available for Özsin 2018 in Bursa, Turkey, where 50 participants were randomized to the vitamin D arm; the dose, formulation, frequency, and duration were not reported in the provided text.

Key limitation

The evidence was based mainly on observational studies, so causality and supplement efficacy cannot be confirmed.

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Original abstract