Research paper
The Oxford-Durham Study: A Randomized, Controlled Trial of Dietary Supplementation With Fatty Acids in Children With Developmental Coordination Disorder
Citations: 422
Influential: 16
Interventional (Human) Studies
95
Low RoB
Study answer
What this study found
Fatty acid supplementation improved reading, spelling, and teacher-rated behavior, but did not improve motor skills over the 3-month parallel-treatment period. Reading age increased by 9.5 months in the active group versus 3.3 months with placebo (z = 2.87, P < .004), and spelling age increased by 6.6 months versus 1.2 months (z = 3.36, P < .001). Teacher-rated Conners' total raw score fell from 74.7 to 58.1 with active treatment versus 69.5 to 67.9 with placebo (z = 5.48, P < .00001). The authors concluded that the fatty acid regimen may be a safe, tolerable, and potentially efficacious…
- Study & population
- Randomized controlled trial in school-age children with developmental coordination disorder identified from mainstream schools in County Durham, United Kingdom.
- Intervention
- Children in the active arm received a daily capsule regimen of 80% fish oil and 20% evening primrose oil for 3 months.
- Key limitation
- The parallel phase was short at 3 months, and the active-arm sample was modest, limiting precision and long-term inference.
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