The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial

Study answer

What this study found

Synbiotic supplementation alongside periodontal therapy was associated with clinically and biologically favorable changes in periodontal status and oxidative stress markers. In the intervention arm, probing depth decreased from 4.30 ± 0.76 mm to 3.47 ± 0.79 mm (p<0.001), clinical attachment level decreased from 3.26 ± 0.61 mm to 2.73 ± 0.75 mm (p=0.002), IL-1β decreased from 2.64 ± 0.41 to 2.19 ± 0.48 pg/mL (p<0.001), and MDA decreased from 18.25 ± 1.89 to 17.22 ± 1.82 µM (p<0.001). Antioxidant markers also improved, including TAC from 0.588 ± 0.08 to 0.636 ± 0.09, SOD from 14.32 ± 2.52 to…

Study & population

Double-blind, placebo-controlled trial in adults with type 2 diabetes mellitus and chronic periodontitis receiving non-surgical periodontal therapy.

Intervention

Adults in the active arm received 1 oral capsule daily of a multispecies synbiotic supplement (500 mg) for 8 weeks.

Key limitation

The active-arm sample was small (N=23), limiting precision and generalizability.

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Original abstract