The Impact of Glucomannan, Inulin, and Psyllium Supplementation (SolowaysTM) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial

Study answer

What this study found

The fiber supplement produced greater weight loss and better body composition outcomes than placebo, with larger responses in homozygous minor allele carriers. From baseline to day 180, weight change was -7.3% with active treatment versus -2.4% with placebo, and absolute weight loss was -6.5 kg versus -2.2 kg (both p < 0.01); 59.2% reached at least 5% weight loss versus 26.5% with placebo, and 21.1% reached at least 10% versus 8.8% with placebo. BMI fell by -2.2 kg/m2 versus -0.8 kg/m2, fat mass by -19.4% versus -6.4%, and visceral fat rating by -1.9 versus -0.6, all favoring the supplement…

Study & population

Randomized, double-blind, placebo-controlled trial in adults with obesity carrying at least one minor allele in FTO, LEP, LEPR, or MC4R.

Intervention

Participants in the active group received an oral fiber powder taken three times daily, one bag 30 minutes before breakfast, lunch, and dinner, for 180 days.

Key limitation

The trial was relatively short at 180 days and involved a genetically selected obesity population, which limits generalizability.

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Original abstract