Research paper
The efficacy and safety of post-stroke cognitive impairment therapies: an umbrella review
Study answer
What this study found
Overall, several therapies showed improvements in cognition or function, but the evidence was heterogeneous and not definitive. Reported benefits included NBP improving MMSE by MD 4.89 (95% CI 4.14 to 5.63), citicoline improving NIHSS by MD -1.82 (95% CI -2.25 to -1.40), and salvianolate improving NIHSS by MD -2.42 (95% CI -2.86 to -1.98). Acupuncture, memantine, donepezil, oxiracetam, oxygen, and other regimens also showed positive signals on selected outcomes, and adverse effects were generally mild. No significant adverse-event differences were reported for donepezil, actovegin,…
- Study & population
- Umbrella review of systematic reviews and meta-analyses in stroke survivors with post-stroke cognitive impairment.
- Intervention
- This umbrella review did not test a single supplement regimen; it synthesized multiple active post-stroke cognitive impairment therapies versus placebo or control.
- Key limitation
- Evidence was drawn from an umbrella review of heterogeneous therapies, outcomes, and underlying review quality rather than a single standardized intervention.
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Open PDFOriginal abstract
Background: Stroke survivors are at significantly increased risk of cognitive impairment, which affects patients’ independence of activities of daily living (ADLs), social engagement, and neurological function deficit. Many studies have been done to …