The effects of Taurine supplementation on inflammatory markers and clinical outcomes in patients with traumatic brain injury: a double-blind randomized controlled trial

What this study found

Taurine supplementation significantly reduced serum IL-6 levels, marginally decreased APACHE II scores, and prevented significant weight loss, while improving Glasgow Coma Scale scores. No significant differences were noted in other inflammatory markers or clinical outcomes like ICU stay length.

Study & population

Patients with TBI aged over 18, with a GCS score of 6-12, were included.

Intervention

32 patients with TBI were randomized into two groups; one received 30 mg/kg/day of taurine in addition to a standard enteral meal for 14 days.

Key limitation

Small sample size, short duration of supplementation, no measurement of plasma taurine concentration.

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