Research paper
The effects of selenium supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy: a randomised, double-blind, placebo-controlled trial
Study answer
What this study found
Selenium supplementation showed favorable effects on several inflammation and oxidative stress biomarkers, but the findings were mixed rather than uniformly positive. Compared with placebo, unadjusted changes favored selenium for hs-CRP (-1069.2 ng/ml vs -135.3 ng/ml, P = 0.02), MMP-2 (-612.3 ng/ml vs +76.0 ng/ml, P < 0.001), MDA (-0.1 µmol/l vs +0.4 µmol/l, P = 0.01), TAC (+174.9 vs +15.8 mmol/l, P = 0.04), and GPx (+2.3 U/ml vs -27.7 U/ml, P = 0.001). After adjustment for baseline biochemical values, age, and BMI, NO (P = 0.02) and GSH (P < 0.001) remained significant, while hs-CRP (P =…
- Study & population
- Randomized, double-blind, placebo-controlled trial in adults with diabetic nephropathy and proteinuria at Shahid Beheshti Clinic in Kashan, Iran.
- Intervention
- The active regimen was 200 µg/day selenium as selenium yeast capsules for 12 weeks, compared with identical placebo capsules.
- Key limitation
- The trial was small and short term, with only 12 weeks of follow-up and limited power for clinical outcomes.
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Open PDFOriginal abstract
Abstract This study was carried out to assess the effects of Se supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy (DN). This randomised, double-blind, placebo-controlled clinical trial was conduc…