Research paper
The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis
Study answer
What this study found
Overall, probiotics during pregnancy were associated with better glucose metabolism, with several trials reporting lower fasting glucose, insulin, HOMA-IR, or improved QUICKI in healthy and GDM pregnancies. Notable study-level findings included reduced plasma glucose and improved insulin sensitivity in one healthy-pregnancy trial (P = 0.025 and P = 0.028), reduced GDM frequency in another healthy-pregnancy trial (P = 0.03), and improvements in fasting glucose, insulin resistance, and related markers in multiple GDM trials. Lipid effects were inconsistent: some GDM studies reported lower…
- Study & population
- Evidence-based meta-analysis of probiotic supplementation studies in pregnant women, including healthy pregnancies, women with overweight or obesity, and women with gestational diabetes mellitus.
- Intervention
- Pregnant participants received oral probiotic supplements containing various Lactobacillus and Bifidobacterium strains, including L.
- Key limitation
- The evidence base was small and heterogeneous, with different probiotic strains, doses, start times, and treatment durations across studies.
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Open PDFOriginal abstract
The prevalence of maternal obesity and gestational diabetes mellitus (GDM) is increasing rapidly. Probiotics supplementation have been shown to improve metabolic health in humans. In our study, we aimed to evaluate the effects of probiotics supplemen…