Research paper
The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome
Citations: 69
Influential: 8
Interventional (Human) Studies
85
Study answer
What this study found
Omega-3 fatty acids plus vitamin E improved PCOS-related biomarker profiles after 12 weeks. Lp(a) mRNA and Ox-LDL mRNA were both downregulated versus placebo (P<0.001 for both). Compared with placebo, triglycerides decreased by -22.1±22.3 mg/dL versus +7.7±23.6, VLDL by -4.4±4.5 versus +1.5±4.7, total cholesterol by -20.3±16.6 versus +12.2±26.1, LDL-cholesterol by -16.7±15.3 versus +11.9±26.1, and total-/HDL-cholesterol by -0.5±0.6 versus +0.4±0.8. TAC increased and MDA decreased relative to placebo, while HDL-cholesterol and GSH did not show a meaningful effect.
- Study & population
- A 12-week placebo-controlled study in women with polycystic ovary syndrome aged 18-40 years in Kashan, Iran.
- Intervention
- Omega-3 fatty acids from flaxseed oil 1000 mg, providing 400 mg alpha-linolenic acid, plus vitamin E 400 IU, administered orally as capsules for 12 weeks and compared with placebo.
- Key limitation
- The trial was small, single-center, and only 12 weeks long, which limits confidence and generalizability.
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